| UniProt/SwissProt ID: | MCHR2_HUMAN |
| Description: | melanin-concentrating hormone receptor 2 [Source:HGNC Symbol;Acc:20867] |
| Location: | chr6 q16.2 |
| Node attribute: | receptor; GPCR |
| Phosphorylation site |
| MCHR2_HUMAN do not have phosphorylation site. |
| Dephosphorylation site |
| MCHR2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000358214 | Y132N | COSMIC | Breast Cancer | 20668451 | ENSP00000358214 | I83V | COSMIC | Lung Cancer | 20668451 | ENSP00000358214 | Q314R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000358214 | V253M | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000358214 | A297D | COSMIC | Lung Cancer | 20668451 | ENSP00000358214 | G96E | COSMIC | Skin Cancer | 21984974 | ENSP00000358214 | S338L | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000358214 | C8F | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000358214 | P266A | COSMIC | Lung Cancer | 20668451 | ENSP00000358214 | E14K | COSMIC | Melanoma | 21499247 | ENSP00000358214 | R140* | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| MCHR2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MCHR2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MCH_HUMAN | MCHR2_HUMAN | ligand -> receptor | HPMR |
| MCHR2_HUMAN | GNA11_HUMAN | GPCR -> Gprotein | gpDB |
| MCHR2_HUMAN | GNAQ_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |