Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MAP2_HUMAN
Description:microtubule-associated protein 2 [Source:HGNC Symbol;Acc:6839]
Location:chr2 q34
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S530RLSNVsSSGSIHPRD
T1599TTPGStAITPGDUF1880PhosphoSitePlus
T1813SPQLAtLAEDVPhosphoSitePlus
S446VSSSGsINLLEMARK1HPRD
S1675LKNVKsKIGSTPRKACAHPRD
S1679KSKIGsTDNIKTubulin-bindingPhosphoSitePlus
S1347EPKDGsPEAPAHPRD; RegPhos
S1158ETSPEsSLIQDMAP2_projctnPhosphoSitePlus
S1155GKKETsPESSLHPRD; RegPhos
S1155GKKETsPESSLMAP2_projctnPhosphoSitePlus
T860HVIVKtDSQLEMAP2_projctnPhosphoSitePlus
S475SNVSSsGSINLHPRD
S444SNVSSsGSINLHPRD
T424GAEIItQSPGRHPRD
S1795SPRRLsNVSSSPhosphoSitePlus
S1534DGVTKsPEKRSPhosphoSitePlus; RegPhos
S1802VSSSGsINLLEMARK1HPRD; RegPhos
S534VSSSGsINLLEHPRD
Y1609GTPPSySSRTPDUF1880PhosphoSitePlus
S654PEEPSsPQERMHPRD; RegPhos
S252PGTPPsYSSRTHPRD
S1347EPKDGsPEAPAMAP2_projctnPhosphoSitePlus
T1595TSTPTtPGSTADUF1880PhosphoSitePlus
T1819LAEDVtAALAKPhosphoSitePlus
S1540PEKRSsLPRPSMARK1HPRD; RegPhos
S843TVVEDsRTGLPMAP2_projctnPhosphoSitePlus
T263PGTPGtPSYPRHPRD
S1802VSSSGsINLLEPhosphoSitePlus; RegPhos
T1602GSTAItPGTPPHPRD; RegPhos
T455GAEIItQSPGRHPRD
S1539SPEKRsSLPRPPhosphoSitePlus
S862IVKTDsQLEDLMAP2_projctnPhosphoSitePlus
S184PEKRSsLPRPSMARK1HPRD
T1656PKSPAtPKQLRPhosphoSitePlus
T1366LSEYKtETYDDMAP2_projctnPhosphoSitePlus
S610SIDTMsPMHKNHPRD; RegPhos
T290SPGPLtPMREKPhosphoSitePlus
T1154EGKKEtSPESSMAP2_projctnPhosphoSitePlus
S729LSPLAsDILTNHPRD; RegPhos
S527SPRRLsNVSSSHPRD
S385TSKCGsLKNIRMARK1HPRD
T1494PAIKYtRPTHLMAP2_projctnPhosphoSitePlus
S823RLASVsADAEVMAP2_projctnPhosphoSitePlus
S1588RRAGKsGTSTPDUF1880PhosphoSitePlus
T323QGGSFtLPLDVPhosphoSitePlus
S1653RTPPKsPATPKPhosphoSitePlus
T238GTSTPtTPGSTHPRD
T249AITPGtPPSYSHPRD
T1780GAEIItQSPGRPhosphoSitePlus; HPRD
T1440RGRIStPERKVRegPhos
T1440RGRIStPERKVMAP2_projctnPhosphoSitePlus
S532SNVSSsGSINLHPRD
S477VSSSGsINLLEMARK1HPRD
Y67GSQGTySNTKEFynphosphoELM; RegPhos
T1613SYSSRtPGTPGRegPhos
S514EIITQsPGRSSHPRD
T1154EGKKEtSPESSHPRD
T320PGTPGtPSYPRHPRD
S1710TSKCGsLKNIRTubulin-bindingPhosphoSitePlus
S1608PGTPPsYSSRTDUF1880PhosphoSitePlus
T1649VAIIRtPPKSPPhosphoSitePlus; RegPhos
S1786QSPGRsSVASPPhosphoSitePlus
S1798RLSNVsSSGSIPhosphoSitePlus; HPRD; RegPhos
S1480EVQAHsPSRKFRegPhos
S1591GKSGTsTPTTPDUF1880PhosphoSitePlus
Y67GSQGTySNTKELynphosphoELM; RegPhos
S1598PTTPGsTAITPDUF1880PhosphoSitePlus
S1787SPGRSsVASPRPhosphoSitePlus
T1594GTSTPtTPGSTDUF1880PhosphoSitePlus
S1611PPSYSsRTPGTRegPhos
T516AMTSKtLEKAMMAP2_projctnPhosphoSitePlus
T1592KSGTStPTTPGDUF1880PhosphoSitePlus
S474LSNVSsSGSINMARK1HPRD
S833VARRKsVPSETMAP2_projctnPhosphoSitePlus
S1591GKSGTsTPTTPRegPhos
T1108TKVSEtEVKEKMAP2_projctnPhosphoSitePlus
Y592EPGSDyYELSDMAP2_projctnPhosphoSitePlus
Y745DEGDDyLPATTRegPhos
S439SPRRLsNVSSSMARK1HPRD
T1605AITPGtPPSYSHPRD; RegPhos
S1564DENSFsLNSSIDUF1880PhosphoSitePlus
T1631PHTPGtPKSAIPhosphoSitePlus
S821RSRLAsVSADAHPRD; RegPhos
S457EIITQsPGRSSHPRD
T246GSTAItPGTPPHPRD
S821RSRLAsVSADAMAP2_projctnPhosphoSitePlus
Y67GSQGTySNTKEPhosphoSitePlus
S63FGEHGsQGTYSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T66HGSQGtYSNTKPhosphoSitePlus
T1497KYTRPtHLSCVMAP2_projctnPhosphoSitePlus
S1106EGTKVsETEVKMAP2_projctnPhosphoSitePlus
S1795SPRRLsNVSSSMARK1HPRD; RegPhos
Y1369YKTETyDDYKDMAP2_projctnPhosphoSitePlus
S1679KSKIGsTDNIKMARK1HPRD; RegPhos
S1353PEAPAsPEREEHPRD; RegPhos
T1595TSTPTtPGSTARegPhos
S323KSKIGsTDNIKMARK1HPRD
T1605AITPGtPPSYSDUF1880PhosphoSitePlus
S319LKNVKsKIGSTPRKACAHPRD
T1619PGTPGtPSYPRPhosphoSitePlus; HPRD; SysPTM
S1710TSKCGsLKNIRMARK1HPRD; RegPhos
S354TSKCGsLKNIRMARK1HPRD
S1799LSNVSsSGSINPhosphoSitePlus; RegPhos
S1421EARRSsLEKHRRegPhos
S833VARRKsVPSETphosphoELM; RegPhos
T1616SRTPGtPGTPSRegPhos
T512GAEIItQSPGRHPRD
S470SPRRLsNVSSSMARK1HPRD
S1800SNVSSsGSINLPhosphoSitePlus; HPRD; RegPhos
S1234PAEIQsEEEEIMAP2_projctnPhosphoSitePlus
S531LSNVSsSGSINHPRD
S1324VERRPsPHDEEMAP2_projctnPhosphoSitePlus
T1602GSTAItPGTPPDUF1880PhosphoSitePlus
T1590AGKSGtSTPTTDUF1880PhosphoSitePlus
S1702KKIDLsHVTSKTubulin-bindingPhosphoSitePlus
S285LVAPIsPGPLTPhosphoSitePlus
S385AEAPPsEAMTLMARK1RegPhos
S1540PEKRSsLPRPSPhosphoSitePlus
S1675LKNVKsKIGSTPKACaRegPhos
S1782EIITQsPGRSSPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T1368EYKTEtYDDYKMAP2_projctnPhosphoSitePlus
S1608PGTPPsYSSRTHPRD; RegPhos
S629KESQPsPPAQERegPhos
S443LSNVSsSGSINMARK1HPRD
S1500RPTHLsCVKRKMAP2_projctnPhosphoSitePlus
S1706LSHVTsKCGSLTubulin-bindingPhosphoSitePlus
S736ILTNTsGSMDERegPhos
S1234PAEIQsEEEEIHPRD
S1790RSSVAsPRRLSPhosphoSitePlus; RegPhos
S1353PEAPAsPEREEMAP2_projctnPhosphoSitePlus
S473RLSNVsSSGSIHPRD
S442RLSNVsSSGSIHPRD
T1594GTSTPtTPGSTHPRD; RegPhos
S426EIITQsPGRSSHPRD
S1799LSNVSsSGSINMARK1HPRD; RegPhos

Dephosphorylation site
MAP2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000353508N132SBIOMARTBreast Cancer21930507, 21930502
ENSP00000353508T20KCOSMICOvarian Cancer21720365
ENSP00000392164K526NBIOMARTBreast Cancer21930507, 21930502
ENSP00000353508D617NCOSMICHead and Neck Cancer21798897
ENSP00000353508D1380NBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000353508E837QCOSMICOvarian Cancer21720365
ENSP00000199940G379ATCGAOvarian Cancer21720365, 18772890
ENSP00000353508E1181DCOSMICPancreatic Cancer
ENSP00000376032N132SBIOMARTBreast Cancer21930507, 21930502
ENSP00000353508G1678ACOSMICOvarian Cancer21720365
ENSP00000353508P705LCOSMICIntestines Cancer16959974
ENSP00000353508H27DCOSMICOvarian Cancer21720365
ENSP00000353508Q1340*COSMICSkin Cancer21984974
ENSP00000199940G38ETCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000353508E754GCOSMICOvarian Cancer21720365
ENSP00000353508D825HCOSMICHead and Neck Cancer21798897
ENSP00000355290N132SBIOMARTBreast Cancer21930507, 21930502
ENSP00000353508G38ECOSMICCentral Nervous System Neoplasms18772890
ENSP00000353508E277DCOSMICIntestines Cancer16959974
ENSP00000353508Q1086*COSMICHead and Neck Cancer21798893
ENSP00000353508K530NBIOMARTBreast Cancer21930507, 21930502
ENSP00000353508P705LHPIColorectal Cancer16959974
ENSP00000353508V1476ACOSMICOvarian Cancer21720365
ENSP00000353508E277DHPIColorectal Cancer16959974
ENSP00000353508Q308KBIOMARTGastric Cancer21930507, 21930502
ENSP00000392164N132SBIOMARTBreast Cancer21930507, 21930502
ENSP00000353508Q34KCOSMICOvarian Cancer21720365
ENSP00000199940N132SBIOMARTBreast Cancer21930507, 21930502
ENSP00000199940H27DTCGAOvarian Cancer21720365, 18772890
ENSP00000353508A826TBIOMARTGastric Cancer21930507, 21930502
ENSP00000353508T1433PCOSMICHead and Neck Cancer21798893

Differential expressed protein
MAP2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S1702Tubulin-bindingVTKKIDLsHVTSKCGAlzheimer's disease21828286PhosphoSitePlus
S1706Tubulin-bindingIDLSHVTsKCGSLKNAlzheimer's disease21828286PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANMAP2_HUMANkinase -> substrateHPRD
MARK1_HUMANMAP2_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANMAP2_HUMANkinase -> substrateRegPhos
LYN_HUMANMAP2_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANMAP2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
MAP2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005874microtubuleIEAcellular_component
GO:0071310cellular response to organic substanceIEAbiological_process
GO:0021954central nervous system neuron developmentIEPbiological_process
GO:0005622intracellularIEAcellular_component
GO:0016358dendrite developmentIEAbiological_process
GO:0018107peptidyl-threonine phosphorylationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005516calmodulin bindingIEAmolecular_function
GO:0015631tubulin bindingIEAmolecular_function
GO:0031175neuron projection developmentIEPbiological_process
GO:0043198dendritic shaftIEAcellular_component
GO:0043025neuronal cell bodyIEAcellular_component
GO:0048813dendrite morphogenesisIEPbiological_process
GO:0034399nuclear peripheryIEAcellular_component
GO:0002162dystroglycan bindingIPImolecular_function
GO:0007409axonogenesisIEAbiological_process
GO:0044297cell bodyIEAcellular_component
GO:0005875microtubule associated complexTAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0001578microtubule bundle formationIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0005198structural molecule activityNASmolecular_function