Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:M4K4_HUMAN
Description:mitogen-activated protein kinase kinase kinase kinase 4 [Source:HGNC Symbol;Acc:6866]
Location:chr2 q11.2
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S644SPLQGsGQQNSPhosphoSitePlus
T181AQLDRtVGRRNphosphoELM
T830SSSSFtPFIDPHPRD
S602PSRSEsFSNGNPhosphoSitePlus; phosphoELM
Y992DKLRVyYLSWLCNHPhosphoSitePlus
T35VVGNGtYGQVYPkinasePhosphoSitePlus
Y321KDETEyEYSGSHPRD
Y323ETEYEySGSEEPhosphoSitePlus
S825LQKHKsSSSFTHPRD
Y520QQEQAyLLSLQPhosphoSitePlus
S854KHKSSsSFTPFPhosphoSitePlus
S625AGQRNsTSSIEHPRD
T1230QVYFMtLGRTSPhosphoSitePlus
S773DTRAAsSLNLSHPRD
T840LIVRQtQSASSPhosphoSitePlus
S666GSHPGsQSGSGHPRD
S604RSESFsNGNSEPhosphoSitePlus
S784NGETEsVKTMIHPRD
S871QISPSsGTTVTPhosphoSitePlus
Y193FIGTPyWMAPEPkinasePhosphoSitePlus
Y560EPKAHyEPADRPhosphoSitePlus
S828HKSSSsFTPFIHPRD
S629PVRTTsRSPVLPhosphoSitePlus; phosphoELM
S647VPRPGsGSSSGHPRD
S350NVPGEsTLRRDHPRD
S877GTTVTsVVGFSPhosphoSitePlus
S600PVPSRsESFSNPhosphoSitePlus
S700GSQSGsGERFRPhosphoSitePlus
S523QAYLLsLQHDHPhosphoSitePlus
T907VNVNPtNTRPQPhosphoSitePlus
T857SSSSFtPFIDPPhosphoSitePlus
S698HPGSQsGSGERPhosphoSitePlus
S683GSSSGsSNSGSPhosphoSitePlus
S800DTRAAsSLNLSPhosphoSitePlus
T846QSASStLQKHKPhosphoSitePlus
S681GSGSSsGSSNSPhosphoSitePlus
S639LSRRDsPLQGSPhosphoSitePlus; phosphoELM; SysPTM
S717SEGSPsQRLENPhosphoSitePlus
Y86NIATYyGAFIKPkinasePhosphoSitePlus
S900PTRKGsVVNVNPhosphoSitePlus; phosphoELM
S709FRVRSsSKSEGPhosphoSitePlus
S679RPGSGsSSGSSPhosphoSitePlus
T834PSKEGtLIVRQPhosphoSitePlus
S656AGQRNsTSIEPphosphoELM
T597VPVRTtSRSPVHPRD
S5AKSLHPRD
T319GEKDEtEYEYSHPRD
S631RTTSRsPVLSRPhosphoSitePlus; phosphoELM
S708RFRVRsSSKSEPhosphoSitePlus
T888RPQSDtPEIRKHPRD
T828SEPAMtPSKEGPhosphoSitePlus
S685SKSEGsPSQRLHPRD
S628RNSTSsIEPRLHPRD
S805SSLNLsNGETEPhosphoSitePlus; phosphoELM; SysPTM
T596QVPVRtTSRSPHPRD
S823HDDVEsEPAMTPhosphoSitePlus
T873SPSSGtTVTSVPhosphoSitePlus
T915RPQSDtPEIRKPhosphoSitePlus; phosphoELM
S811NGETEsVKTMIPhosphoSitePlus
S841RLLQIsPSSGTHPRD
S324TEYEYsGSEEEPhosphoSitePlus; HPRD
S686SGSSNsGSQPGPhosphoSitePlus
T627QVPVRtTSRSPPhosphoSitePlus; phosphoELM
S662GSQPGsHPGSQHPRD
S1224RSGGSsQVYFMPhosphoSitePlus
S801TRAASsLNLSNPhosphoSitePlus; phosphoELM
S598PVRTTsRSPVLHPRD
S326YEYSGsEEEEEPhosphoSitePlus; HPRD
T191NTFIGtPYWMAPkinasePhosphoSitePlus
S712RSSSKsEGSPSPhosphoSitePlus
T809LSNGEtESVKTPhosphoSitePlus
S600RTTSRsPVLSRHPRD
T1146GVYVNtYGRITCNHPhosphoSitePlus
Y467EREQEyIRRQLPhosphoSitePlus
S680PGSGSsSGSSNPhosphoSitePlus
S536PHPQHsQQPPPPhosphoSitePlus
S715SKSEGsPSQRLPhosphoSitePlus
S618SGQQNsQAGQRHPRD
S677VPRPGsGSSSGPhosphoSitePlus
S842VRQTQsASSTLPhosphoSitePlus
S696GSHPGsQSGSGPhosphoSitePlus; phosphoELM
S682RSSSKsEGSPSHPRD
S853QKHKSsSSFTPPhosphoSitePlus
T880VNVNPtNTRPQHPRD
S5_MANDsPAKSLPhosphoSitePlus
T187VGRRNtFIGTPPkinasePhosphoSitePlus
S175VDFGVsAQLDRPkinasePhosphoSitePlus
T181AQLDRtVGRRNPkinasePhosphoSitePlus
S815VRQTQsASSTLHPRD
S264SKKFFsFIEGCPkinasePhosphoSitePlus
T628VPVRTtSRSPVPhosphoSitePlus
S692GSQPGsHPGSQPhosphoSitePlus; phosphoELM
Y1227GSSQVyFMTLGPhosphoSitePlus
S868RLLQIsPSSGTPhosphoSitePlus
S913NTRPQsDTPEIPhosphoSitePlus
S995RVYYLsWLRNKCNHPhosphoSitePlus
T351VPGEStLRRDFHPRD
S613SPLQGsGQQNSHPRD
S649SGQQNsQAGQRPhosphoSitePlus
S830PAMTPsKEGTLPhosphoSitePlus
T124NTKGNtLKEDWPkinasePhosphoSitePlus
S774TRAASsLNLSNHPRD
S598EPPVPsRSESFPhosphoSitePlus
S855HKSSSsFTPFIPhosphoSitePlus
S870LQISPsSGTTVPhosphoSitePlus
S684SSSGSsNSGSQPhosphoSitePlus
S886NTRPQsDTPEIHPRD
S608LSRRDsPLQGSHPRD
S710RVRSSsKSEGSPhosphoSitePlus
T801SEPAMtPSKEGHPRD
Y36VGNGTyGQVYKPkinasePhosphoSitePlus
S778SSLNLsNGETEHPRD

Dephosphorylation site
M4K4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000314363D571NBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000314363Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
M4K4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
M4K4_HUMANIKKB_HUMANkinase -> substrateRegPhos
M4K4_HUMANIKKA_HUMANkinase -> substrateRegPhos
M4K4_HUMANM3K1_HUMANkinase -> substrateKEGG
M4K4_HUMANNFKB2_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005524ATP bindingIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0006950response to stressIDAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0007243intracellular protein kinase cascadeIDAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0046328regulation of JNK cascadeIDAbiological_process
GO:0005083small GTPase regulator activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function


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