Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LOX15_HUMAN
Description:arachidonate 15-lipoxygenase [Source:HGNC Symbol;Acc:433]
Location:chr17 p13.2
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y613QHEEEyFSGPELipoxygenasePhosphoSitePlus
Y438GAFLTySSFCPLipoxygenasePhosphoSitePlus
S591ASLQMsITWQLLipoxygenasePhosphoSitePlus
S177VDFEVsLAKGLLipoxygenasePhosphoSitePlus
Y158AGAKLyDLPVDLipoxygenasePhosphoSitePlus

Dephosphorylation site
LOX15_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000293761Q358*COSMICLung Cancer
ENSP00000293761G117CCOSMICOvarian Cancer21720365
ENSP00000293761R500QCOSMICMelanoma
ENSP00000293761*663GCOSMICHead and Neck Cancer21798893
ENSP00000293761Q317*COSMICSkin Cancer21984974

Differential expressed protein
LOX15_HUMAN is not differential expressed protein.

Hyperphosphorylation site
LOX15_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
STAT6_HUMANLOX15_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
LOX15_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006954inflammatory responseTASbiological_process
GO:0006629lipid metabolic processNASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0050473arachidonate 15-lipoxygenase activityIEAmolecular_function
GO:0006691leukotriene metabolic processIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0019370leukotriene biosynthetic processIEAbiological_process
GO:0016165lipoxygenase activityIEAmolecular_function
GO:0030282bone mineralizationIEAbiological_process
GO:0001503ossificationIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005506iron ion bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0055114oxidation-reduction processIEAbiological_process
GO:0016702oxidoreductase activity, acting on single donors wIEAmolecular_function


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