| UniProt/SwissProt ID: | LITAF_HUMAN |
| Description: | lipopolysaccharide-induced TNF factor [Source:HGNC Symbol;Acc:16841] |
| Location: | chr16 p13.13 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y23 | SAPPSyEETVA | PhosphoSitePlus | |
| S105 | NKMIVsQLSYN | zf-LITAF-like | PhosphoSitePlus |
| S105 | NKMIVsQLSYN | HPRD | |
| Y33 | AVNSYyPTPPA | PhosphoSitePlus | |
| Y62 | NPPSYyTQPAP | PhosphoSitePlus | |
| S31 | TVAVNsYYPTP | PhosphoSitePlus | |
| Y32 | VAVNSyYPTPP | PhosphoSitePlus | |
| T63 | PPSYYtQPAPI | PhosphoSitePlus | |
| Y61 | MNPPSyYTQPA | PhosphoSitePlus | |
| Dephosphorylation site |
| LITAF_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000340118 | Y23H | HPI | Other Cancer | 15197774 | ENSP00000340118 | Q64K | COSMIC | Skin Cancer | 21984974 | ENSP00000340118 | Y109fs*6 | COSMIC | Hepatocellular Carcinoma |
| Differential expressed protein |
| LITAF_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| LITAF_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| LITAF_HUMAN | TNFA_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| LITAF_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006357 | regulation of transcription from RNA polymerase II | TAS | biological_process |
| GO:0050699 | WW domain binding | IPI | molecular_function |
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0007165 | signal transduction | IMP | biological_process |
| GO:0032496 | response to lipopolysaccharide | IEA | biological_process |
| GO:0042347 | negative regulation of NF-kappaB import into nucle | IEA | biological_process |
| GO:0005886 | plasma membrane | IMP | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0001817 | regulation of cytokine production | IEA | biological_process |
| GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB c | IMP | biological_process |
| GO:0005765 | lysosomal membrane | IDA | cellular_component |
| GO:0071222 | cellular response to lipopolysaccharide | IEA | biological_process |
| GO:0004871 | signal transducer activity | IMP | molecular_function |