Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LIPS_HUMAN
Description:lipase, hormone-sensitive [Source:HGNC Symbol;Acc:6621]
Location:chr19 q13.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T1015LGQPVtLRVVEAbhydrolase_3PhosphoSitePlus
S855MRRSVsEAALAPhosphoSitePlus; RegPhos
S853EPMRRsVSEAAPKACaRegPhos
S951HPRRSsQGATQPRKACAHPRD
S645APRSRsLIVHFPhosphoSitePlus
S855MRRSVsEAALAPKACaRegPhos
S950FHPRRsSQGATAbhydrolase_3PhosphoSitePlus
T189SDKQTtPVQGAHPRD
S855MRRSVsEAALAPRKACAHPRD
S950FHPRRsSQGATPRKACAHPRD
S950FHPRRsSQGATRegPhos
T891ETSSDtPEMSLErk1RegPhos
T891ETSSDtPEMSLErk2RegPhos
S196VQGAKsKQGSLPhosphoSitePlus; RegPhos
Y741LRAAAyGVRVPAbhydrolase_3PhosphoSitePlus
S853EPMRRsVSEAAPhosphoSitePlus; phosphoELM; RegPhos
S855MRRSVsEAALAPKA_groupphosphoELM
S565ATVRVsRLLSLHPRD; RegPhos
S324IAFFSsQGPGEHSL_NPhosphoSitePlus
S853EPMRRsVSEAAPRKACAHPRD
S855MRRSVsEAALAAMPK_groupphosphoELM; RegPhos
S951HPRRSsQGATQRegPhos
S951HPRRSsQGATQPKA_groupphosphoELM; RegPhos
S951HPRRSsQGATQAbhydrolase_3PhosphoSitePlus
S950FHPRRsSQGATPKA_groupphosphoELM; RegPhos
T313TQSLVtLAEDNHSL_NPhosphoSitePlus
T188QSDKQtTPVQGPhosphoSitePlus; HPRD
T891ETSSDtPEMSLMAPK3HPRD
T891ETSSDtPEMSLMAPK1HPRD
S853EPMRRsVSEAAPKA_groupphosphoELM; RegPhos
S950FHPRRsSQGATPKACaRegPhos
T330QGPGEtAQRLSHSL_NPhosphoSitePlus
S951HPRRSsQGATQPKACaRegPhos

Dephosphorylation site
LIPS_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000244289P146QSjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000244289G883RCOSMICOvarian Cancer21720365

Differential expressed protein
LIPS_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S853IAEPMRRsVSEAALAobesity, hyperphagic18398140PhosphoSitePlus
S950Abhydrolase_3EGFHPRRsSQGATQMobesity, hyperphagic18398140PhosphoSitePlus
S855EPMRRSVsEAALAQPobesity, hyperphagic18398140PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANLIPS_HUMANkinase -> substrateKEGG; HPRD
MK01_HUMANLIPS_HUMANkinase -> substrateHPRD
MK03_HUMANLIPS_HUMANkinase -> substrateHPRD
ZAGL2_HUMANLIPS_HUMANkinase -> substrateRegPhos
AAPK2_HUMANLIPS_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04910Insulin signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0019901protein kinase bindingIEAmolecular_function
GO:0019433triglyceride catabolic processIEAbiological_process
GO:0016042lipid catabolic processIEAbiological_process
GO:0016787hydrolase activityIEAmolecular_function
GO:0033878hormone-sensitive lipase activityIEAmolecular_function
GO:0005811lipid particleIEAcellular_component
GO:0005901caveolaIEAcellular_component
GO:0004806triglyceride lipase activityIEAmolecular_function
GO:0005811lipid particleISScellular_component
GO:0006629lipid metabolic processTASbiological_process
GO:0016298lipase activityIEAmolecular_function
GO:0046340diacylglycerol catabolic processIEAbiological_process
GO:0006468protein phosphorylationTASbiological_process
GO:0005829cytosolIEAcellular_component
GO:0008152metabolic processIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0016042lipid catabolic processISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0008203cholesterol metabolic processIEAbiological_process


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