Phosphorylation

Protein information

UniProt/SwissProt ID:	LIPS_HUMAN
Description:	lipase, hormone-sensitive [Source:HGNC Symbol;Acc:6621]
Location:	chr19 q13.2
Node attribute:	substrate

Position	PhosphoPeptide	Catalytic kinase	Source
T1015	LGQPVtLRVVE	Abhydrolase_3	PhosphoSitePlus
S855	MRRSVsEAALA		PhosphoSitePlus; RegPhos
S853	EPMRRsVSEAA	PKACa	RegPhos
S951	HPRRSsQGATQ	PRKACA	HPRD
S645	APRSRsLIVHF		PhosphoSitePlus
S855	MRRSVsEAALA	PKACa	RegPhos
S950	FHPRRsSQGAT	Abhydrolase_3	PhosphoSitePlus
T189	SDKQTtPVQGA		HPRD
S855	MRRSVsEAALA	PRKACA	HPRD
S950	FHPRRsSQGAT	PRKACA	HPRD
S950	FHPRRsSQGAT		RegPhos
T891	ETSSDtPEMSL	Erk1	RegPhos
T891	ETSSDtPEMSL	Erk2	RegPhos
S196	VQGAKsKQGSL		PhosphoSitePlus; RegPhos
Y741	LRAAAyGVRVP	Abhydrolase_3	PhosphoSitePlus
S853	EPMRRsVSEAA		PhosphoSitePlus; phosphoELM; RegPhos
S855	MRRSVsEAALA	PKA_group	phosphoELM
S565	ATVRVsRLLSL		HPRD; RegPhos
S324	IAFFSsQGPGE	HSL_N	PhosphoSitePlus
S853	EPMRRsVSEAA	PRKACA	HPRD
S855	MRRSVsEAALA	AMPK_group	phosphoELM; RegPhos
S951	HPRRSsQGATQ		RegPhos
S951	HPRRSsQGATQ	PKA_group	phosphoELM; RegPhos
S951	HPRRSsQGATQ	Abhydrolase_3	PhosphoSitePlus
S950	FHPRRsSQGAT	PKA_group	phosphoELM; RegPhos
T313	TQSLVtLAEDN	HSL_N	PhosphoSitePlus
T188	QSDKQtTPVQG		PhosphoSitePlus; HPRD
T891	ETSSDtPEMSL	MAPK3	HPRD
T891	ETSSDtPEMSL	MAPK1	HPRD
S853	EPMRRsVSEAA	PKA_group	phosphoELM; RegPhos
S950	FHPRRsSQGAT	PKACa	RegPhos
T330	QGPGEtAQRLS	HSL_N	PhosphoSitePlus
S951	HPRRSsQGATQ	PKACa	RegPhos

LIPS_HUMAN do not have dephosphorylation site.

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000244289	P146Q	Sjoblom2006, COSMIC, HPI	Breast Cancer	16959974
ENSP00000244289	G883R	COSMIC	Ovarian Cancer	21720365

LIPS_HUMAN is not differential expressed protein.

Site	Motif	Peptide	Cancer name	Pubmed	Source
S853		IAEPMRRsVSEAALA	obesity, hyperphagic	18398140	PhosphoSitePlus
S950	Abhydrolase_3	EGFHPRRsSQGATQM	obesity, hyperphagic	18398140	PhosphoSitePlus
S855		EPMRRSVsEAALAQP	obesity, hyperphagic	18398140	PhosphoSitePlus

Source	Target	Relationship	Resource
KPCA_HUMAN	LIPS_HUMAN	kinase -> substrate	KEGG; HPRD
MK01_HUMAN	LIPS_HUMAN	kinase -> substrate	HPRD
MK03_HUMAN	LIPS_HUMAN	kinase -> substrate	HPRD
ZAGL2_HUMAN	LIPS_HUMAN	kinase -> substrate	RegPhos
AAPK2_HUMAN	LIPS_HUMAN	kinase -> substrate	RegPhos

KEGG Pathway

KEGG ID	Pathway
hsa04910	Insulin signaling pathway

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0019901	protein kinase binding	IEA	molecular_function
GO:0019433	triglyceride catabolic process	IEA	biological_process
GO:0016042	lipid catabolic process	IEA	biological_process
GO:0016787	hydrolase activity	IEA	molecular_function
GO:0033878	hormone-sensitive lipase activity	IEA	molecular_function
GO:0005811	lipid particle	IEA	cellular_component
GO:0005901	caveola	IEA	cellular_component
GO:0004806	triglyceride lipase activity	IEA	molecular_function
GO:0005811	lipid particle	ISS	cellular_component
GO:0006629	lipid metabolic process	TAS	biological_process
GO:0016298	lipase activity	IEA	molecular_function
GO:0046340	diacylglycerol catabolic process	IEA	biological_process
GO:0006468	protein phosphorylation	TAS	biological_process
GO:0005829	cytosol	IEA	cellular_component
GO:0008152	metabolic process	IEA	biological_process
GO:0044281	small molecule metabolic process	TAS	biological_process
GO:0016042	lipid catabolic process	ISS	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0008203	cholesterol metabolic process	IEA	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network