| UniProt/SwissProt ID: | LIME1_HUMAN |
| Description: | Lck interacting transmembrane adaptor 1 [Source:HGNC Symbol;Acc:26016] |
| Location: | chr20 q13.33 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y200 | QVDVLySRVCK | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| Y145 | GLEATySNVGL | PhosphoSitePlus; RegPhos | |
| Y254 | PLENVyESIRE | LCK | RegPhos |
| S256 | ENVYEsIRELG | PhosphoSitePlus | |
| Y235 | AGDLAyQTLPL | PhosphoSitePlus; RegPhos | |
| S95 | ALRPAsMDLLR | PhosphoSitePlus | |
| Y254 | PLENVyESIRE | PhosphoSitePlus | |
| S201 | VDVLYsRVCKP | PhosphoSitePlus; HPRD | |
| Y167 | PVVAEyARVQK | PhosphoSitePlus; HPRD; RegPhos | |
| Dephosphorylation site |
| LIME1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000309521 | Q114* | COSMIC | Hepatocellular Carcinoma | 21822264 |
| Differential expressed protein |
| LIME1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| LIME1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| LCK_HUMAN | LIME1_HUMAN | kinase -> substrate | RegPhos; NetPath |
| LYN_HUMAN | LIME1_HUMAN | kinase -> substrate | NetPath |
| ZAGL2_HUMAN | LIME1_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| LIME1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0051279 | regulation of release of sequestered calcium ion i | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0070851 | growth factor receptor binding | IEA | molecular_function |
| GO:0019815 | B cell receptor complex | IEA | cellular_component |
| GO:0043122 | regulation of I-kappaB kinase/NF-kappaB cascade | IEA | biological_process |
| GO:0043405 | regulation of MAP kinase activity | IEA | biological_process |
| GO:0006357 | regulation of transcription from RNA polymerase II | IEA | biological_process |
| GO:0014066 | regulation of phosphatidylinositol 3-kinase cascad | IEA | biological_process |
| GO:0050853 | B cell receptor signaling pathway | IEA | biological_process |
| GO:0019901 | protein kinase binding | IEA | molecular_function |
| GO:0050852 | T cell receptor signaling pathway | IEA | biological_process |
| GO:0042345 | regulation of NF-kappaB import into nucleus | IEA | biological_process |