Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LGR5_HUMAN
Description:leucine-rich repeat containing G protein-coupled receptor 5 [Source:HGNC Symbol;Acc:4504]
Location:chr12 q21.1
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y114AFTGLySLKVLPhosphoSitePlus
S590SPLYIsPIKLL7tm_1PhosphoSitePlus
S848RSKHPsLMSINPhosphoSitePlus
T722FGEPStMGYMV7tm_1PhosphoSitePlus
S721PFGEPsTMGYM7tm_1PhosphoSitePlus
T842QTYVWtRSKHPPhosphoSitePlus
S844YVWTRsKHPSLPhosphoSitePlus

Dephosphorylation site
LGR5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000266674S462FCOSMICHead and Neck Cancer21798893
ENSP00000266674L819FCOSMICSkin Cancer21984974
ENSP00000266674M764ICOSMICMelanoma21499247
ENSP00000266674R32MCOSMICLung Cancer20668451
ENSP00000266674P886QCOSMICLung Cancer20668451
ENSP00000266674P714TTCGA, COSMICOvarian Cancer21720365, 18772890
ENSP00000266674S402LCOSMICMelanoma21499247
ENSP00000266674Q350*COSMICPancreatic Cancer21252315
ENSP00000266674V296FCOSMICHead and Neck Cancer21798893
ENSP00000266674S873ICOSMICLung Cancer20668451

Differential expressed protein
LGR5_HUMAN is not differential expressed protein.

Hyperphosphorylation site
LGR5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
RSPO1_HUMANLGR5_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
LGR5_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0048839inner ear developmentIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0016500protein-hormone receptor activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0004930G-protein coupled receptor activityTASmolecular_function


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