| UniProt/SwissProt ID: | LGR5_HUMAN |
| Description: | leucine-rich repeat containing G protein-coupled receptor 5 [Source:HGNC Symbol;Acc:4504] |
| Location: | chr12 q21.1 |
| Node attribute: | receptor |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y114 | AFTGLySLKVL | PhosphoSitePlus | |
| S590 | SPLYIsPIKLL | 7tm_1 | PhosphoSitePlus |
| S848 | RSKHPsLMSIN | PhosphoSitePlus | |
| T722 | FGEPStMGYMV | 7tm_1 | PhosphoSitePlus |
| S721 | PFGEPsTMGYM | 7tm_1 | PhosphoSitePlus |
| T842 | QTYVWtRSKHP | PhosphoSitePlus | |
| S844 | YVWTRsKHPSL | PhosphoSitePlus | |
| Dephosphorylation site |
| LGR5_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000266674 | S462F | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000266674 | L819F | COSMIC | Skin Cancer | 21984974 | ENSP00000266674 | M764I | COSMIC | Melanoma | 21499247 | ENSP00000266674 | R32M | COSMIC | Lung Cancer | 20668451 | ENSP00000266674 | P886Q | COSMIC | Lung Cancer | 20668451 | ENSP00000266674 | P714T | TCGA, COSMIC | Ovarian Cancer | 21720365, 18772890 | ENSP00000266674 | S402L | COSMIC | Melanoma | 21499247 | ENSP00000266674 | Q350* | COSMIC | Pancreatic Cancer | 21252315 | ENSP00000266674 | V296F | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000266674 | S873I | COSMIC | Lung Cancer | 20668451 |
| Differential expressed protein |
| LGR5_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| LGR5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| RSPO1_HUMAN | LGR5_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| LGR5_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0048839 | inner ear development | IEA | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0016500 | protein-hormone receptor activity | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0004930 | G-protein coupled receptor activity | TAS | molecular_function |