| UniProt/SwissProt ID: | LEUK_HUMAN |
| Description: | sialophorin [Source:HGNC Symbol;Acc:11249] |
| Location: | chr16 p11.2 |
| Node attribute: | substrate; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S156 | VTTAAsSLETS | PhosphoSitePlus | |
| S368 | SGSGPsLKGEE | PhosphoSitePlus | |
| T341 | SSRRPtLTTFF | PhosphoSitePlus; HPRD | |
| S363 | MEELKsGSGPS | PhosphoSitePlus | |
| S336 | PDGEGsSRRPT | PhosphoSitePlus | |
| S355 | KSRQGsLAMEE | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| T344 | RPTLTtFFGRR | PhosphoSitePlus | |
| T153 | GAPVTtAASSL | PhosphoSitePlus | |
| S351 | FGRRKsRQGSL | PKCa(PKC alpha | RegPhos |
| S291 | GALVLsRGGKR | PhosphoSitePlus; HPRD | |
| T343 | RRPTLtTFFGR | PhosphoSitePlus | |
| S351 | FGRRKsRQGSL | PKC_alpha | phosphoELM |
| S351 | FGRRKsRQGSL | PhosphoSitePlus; HPRD | |
| S211 | TMTTGsLEPSS | PhosphoSitePlus | |
| S337 | DGEGSsRRPTL | PhosphoSitePlus | |
| S365 | ELKSGsGPSLK | PhosphoSitePlus | |
| T236 | MMSPTtSTNAS | PhosphoSitePlus | |
| S328 | GGDKGsGFPDG | PhosphoSitePlus | |
| Dephosphorylation site |
| LEUK_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000353238 | P116T | TCGA | Neoplasms by Histologic Type | 21720365, 18772890 | ENSP00000378787 | P116T | TCGA | Neoplasms by Histologic Type | 21720365, 18772890 | ENSP00000353238 | P389H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000353238 | P116T | COSMIC | Central Nervous System Neoplasms | 18772890 | ENSP00000455266 | P116T | TCGA | Neoplasms by Histologic Type | 21720365, 18772890 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000353238 | Leukemia | Cancer vs. Cancer (chronic vs. acute leukemia) | cell line | Down | 17449014 | |
| Hyperphosphorylation site |
| LEUK_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | LEUK_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAGL2_HUMAN | LEUK_HUMAN | kinase -> substrate | RegPhos |
| SP1_HUMAN | LEUK_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04514 | Cell adhesion molecules (CAMs) |
| hsa05169 | Epstein-Barr virus infection |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0050776 | regulation of immune response | IEA | biological_process |
| GO:0005604 | basement membrane | IEA | cellular_component |
| GO:0007162 | negative regulation of cell adhesion | IEA | biological_process |
| GO:0001562 | response to protozoan | IEA | biological_process |
| GO:0005615 | extracellular space | IDA | cellular_component |
| GO:0042102 | positive regulation of T cell proliferation | IEA | biological_process |
| GO:0031295 | T cell costimulation | IEA | biological_process |
| GO:0051635 | bacterial cell surface binding | IEA | molecular_function |
| GO:0009986 | cell surface | IDA | cellular_component |
| GO:0007166 | cell surface receptor signaling pathway | IEA | biological_process |
| GO:0042742 | defense response to bacterium | IEA | biological_process |
| GO:0004888 | transmembrane signaling receptor activity | TAS | molecular_function |
| GO:0001931 | uropod | IEA | cellular_component |
| GO:0005887 | integral to plasma membrane | IEA | cellular_component |
| GO:0042535 | positive regulation of tumor necrosis factor biosy | IEA | biological_process |
| GO:0009897 | external side of plasma membrane | IEA | cellular_component |
| GO:0050688 | regulation of defense response to virus | IEA | biological_process |
| GO:0006955 | immune response | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0007163 | establishment or maintenance of cell polarity | TAS | biological_process |
| GO:0042130 | negative regulation of T cell proliferation | IEA | biological_process |
| GO:0006968 | cellular defense response | TAS | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0006935 | chemotaxis | TAS | biological_process |
| GO:0050900 | leukocyte migration | TAS | biological_process |
| GO:0001808 | negative regulation of type IV hypersensitivity | IEA | biological_process |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0045060 | negative thymic T cell selection | IEA | biological_process |
| GO:0050868 | negative regulation of T cell activation | IEA | biological_process |