Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LEG3_HUMAN
Description:lectin, galactoside-binding, soluble, 3 [Source:HGNC Symbol;Acc:6563]
Location:chr14 q22.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T175VIVCNtKLDNNGal-bind_lectinPhosphoSitePlus
Y247LTSASyTMI__Gal-bind_lectinPhosphoSitePlus
S12LHDALsGSGNPCK1a(CK1 alphaRegPhos
Y221AHLLQyNHRVKGal-bind_lectinPhosphoSitePlus
S6MADNFsLHDALCK2a2RegPhos
S12LHDALsGSGNPCK2a2RegPhos
S12LHDALsGSGNPCK2a1RegPhos
Y79PAPGVyPGPPSPhosphoSitePlus
S12LHDALsGSGNPCSNK2A2HPRD
S12LHDALsGSGNPCSNK2A1HPRD
S12LHDALsGSGNPCK1aRegPhos
S12LHDALsGSGNPCK2a1-rsRegPhos
S6HDALCSNK1A1HPRD
S6HDALCSNK2A1HPRD
S6HDALCSNK2A2HPRD
S6HDALCK1_alphaphosphoELM
S6MADNFsLHDALCK1aRegPhos
S12LHDALsGSGNPPhosphoSitePlus; RegPhos
S6MADNFsLHDALCK2a1-rsRegPhos
Y118PLIVPyNLPLPGal-bind_lectinPhosphoSitePlus
S6MADNFsLHDALCK1a(CK1 alphaRegPhos
S12LHDALsGSGNPCK1_alphaphosphoELM
S6MADNFsLHDALPhosphoSitePlus; RegPhos
T133PRMLItILGTVHPRD
S6MADNFsLHDALCK2a1RegPhos
S12LHDALsGSGNPCSNK1A1HPRD
Y107PATGPyGAPAGPhosphoSitePlus

Dephosphorylation site
LEG3_HUMAN do not have dephosphorylation site.

Mutation site
LEG3_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000254301Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.1718646787
ENSP00000254301Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.1118646787
ENSP00000254301papillary thyroid carcinomaNormal vs. CancertissueUp2.316788983
ENSP00000254301papillary thyroid carcinomaNormal vs. CancertissueUp618665625
ENSP00000254301papillary thyroid carcinomaNormal vs. CancertissueUp318665625
ENSP00000254301Non-small cell lung carcinomaMetastasiscell lineUp5.517418446
ENSP00000254301Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineDown0.420804217
ENSP00000254301Breast CancerNormal vs. Cancercell lineDown0.6520543960
ENSP00000254301Breast CancerNormal vs. Cancercell lineDown0.7320543960
ENSP00000254301Breast CancerNormal vs. Cancercell lineDown0.7120543960
ENSP00000254301Breast CancerNormal vs. CancertissueUp20560667
ENSP00000254301Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineDown0.3218973835
ENSP00000254301Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineDown0.2318973835
ENSP00000254301Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineDown0.3319714814
ENSP00000254301Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineDown0.6219714814
ENSP00000254301Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineDown0.7119714814
ENSP00000254301Pancreatic CancerNormal vs. CancertissueUp215526344
ENSP00000254301Pancreatic CancerNormal vs. CancertissueUp42019357035

Hyperphosphorylation site
LEG3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANLEG3_HUMANkinase -> substrateRegPhos
KC1A_HUMANLEG3_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CSK21_HUMANLEG3_HUMANkinase -> substrateHPRD
CSK22_HUMANLEG3_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
LEG3_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0008380RNA splicingIEAbiological_process
GO:0031012extracellular matrixIDAcellular_component
GO:0030154cell differentiationIEAbiological_process
GO:0030246carbohydrate bindingIEAmolecular_function
GO:0005681spliceosomal complexIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0045087innate immune responseTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0006397mRNA processingIEAbiological_process
GO:0001501skeletal system developmentIEAbiological_process
GO:0005578proteinaceous extracellular matrixIEAcellular_component
GO:0030198extracellular matrix organizationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005743mitochondrial inner membraneIDAcellular_component
GO:0019863IgE bindingIEAmolecular_function


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