Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LAS1L_HUMAN
Description:LAS1-like (S. cerevisiae) [Source:HGNC Symbol;Acc:25726]
Location:chrX q12
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S235QDDGKsTESDVPhosphoSitePlus
S523EGSEAsPIGKSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S538DSLYWsVKPASPhosphoSitePlus
S528SPIGKsPYTLDPhosphoSitePlus
S412PALGIsGIRPTHPRD
Y536TLDSLyWSVKPPhosphoSitePlus
S441NARRFsAGQWEPhosphoSitePlus
S261CKKALsHKELYPhosphoSitePlus
T91LAVAStADLIRLas1PhosphoSitePlus
S404LERMLsELPALHPRD
S617STGQEsPTAENPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T619GQESPtAENARPhosphoSitePlus; HPRD
S363GTDPKsHKNVDPhosphoSitePlus
T91LAVAStADLIRHPRD
S127FVNLIsERKTKHPRD
S534PYTLDsLYWSVPhosphoSitePlus
S127FVNLIsERKTKLas1PhosphoSitePlus
S90PLAVAsTADLILas1PhosphoSitePlus
S560QEEQGsVNDVKPhosphoSitePlus; HPRD
S238GKSTEsDVKADPhosphoSitePlus
S90PLAVAsTADLIHPRD

Dephosphorylation site
LAS1L_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000363944E556GCOSMICOvarian Cancer21720365
ENSP00000363944R170CHPIColorectal Cancer16959974
ENSP00000363940Q211EBIOMARTBreast Cancer21930507, 21930502
ENSP00000308649Q211EBIOMARTBreast Cancer21930507, 21930502
ENSP00000363944Q211EBIOMARTBreast Cancer21930507, 21930502
ENSP00000363944C256GCOSMICOvarian Cancer21720365
ENSP00000363937Q169EBIOMARTBreast Cancer21930507, 21930502
ENSP00000363944R170CSjoblom2006, COSMICIntestines Cancer16959974

Differential expressed protein
LAS1L_HUMAN is not differential expressed protein.

Hyperphosphorylation site
LAS1L_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ST17A_HUMANLAS1L_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANLAS1L_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
LAS1L_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005737cytoplasmIDAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0071339MLL1 complexIDAcellular_component
GO:0006364rRNA processingIEAbiological_process


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