| UniProt/SwissProt ID: | KSR2_HUMAN |
| Description: | kinase suppressor of ras 2 [Source:HGNC Symbol;Acc:18610] |
| Location: | chr12 q24.23 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S294 | GTPPPsSRKLI | C1_1 | PhosphoSitePlus |
| T269 | TPNIVtTVTPP | PhosphoSitePlus | |
| T260 | RHAVRtPPRTP | PhosphoSitePlus | |
| S34 | NMIDLsISNLE | PhosphoSitePlus | |
| Y566 | LPASHyYKYKQ | Pkinase | PhosphoSitePlus |
| S394 | SANTLsVPRWS | PhosphoSitePlus | |
| T264 | RTPPRtPNIVT | PhosphoSitePlus | |
| S474 | LVRTEsVPCDI | PhosphoSitePlus | |
| S474 | LVRTEsVPCDI | MARK3 | RegPhos |
| S399 | SVPRWsPQIPR | PhosphoSitePlus | |
| T276 | VTPPGtPPMRK | PhosphoSitePlus | |
| T497 | LHISQtLPKTN | PhosphoSitePlus | |
| T272 | IVTTVtPPGTP | PhosphoSitePlus | |
| S311 | TALHRsKSHEF | C1_1 | PhosphoSitePlus |
| T306 | LIPGFtALHRS | C1_1 | PhosphoSitePlus |
| S939 | RNRRLsHPGHF | PhosphoSitePlus | |
| S490 | KPPRYsDLHIS | PhosphoSitePlus | |
| T290 | LKPPGtPPPSS | PhosphoSitePlus | |
| T270 | PNIVTtVTPPG | PhosphoSitePlus | |
| Dephosphorylation site |
| KSR2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000339952 | R676S | HPI | Lung Cancer | 17344846 |
| Differential expressed protein |
| KSR2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| KSR2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MARK3_HUMAN | KSR2_HUMAN | kinase -> substrate | RegPhos |
| KSR2_HUMAN | KPCA_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KSR2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0035556 | intracellular signal transduction | IEA | biological_process |
| GO:0019722 | calcium-mediated signaling | IEA | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0005078 | MAP-kinase scaffold activity | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0031434 | mitogen-activated protein kinase kinase binding | IEA | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0005829 | cytosol | IEA | cellular_component |
| GO:0043410 | positive regulation of MAPK cascade | IEA | biological_process |