Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KPCD2_HUMAN
Description:protein kinase D2 [Source:HGNC Symbol;Acc:17293]
Location:chr19 q13.32
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S518LQDAPsAPGHAPhosphoSitePlus; HPRD
S242SSSSSsASSYTPhosphoSitePlus
T619ECMFEtPEKVFPkinasePhosphoSitePlus
S876LAERIsHPRD
S236PRRPPsSSSSSPhosphoSitePlus; HPRD
Y272FLIHSyTRPTVC1_1PhosphoSitePlus
S876LAERIsVL___PhosphoSitePlus
T714RSVVGtPAYLAPkinasePhosphoSitePlus
Y378QSSLGyIPLMRPhosphoSitePlus
S189IPNNCsGARKRC1_1; Prok-RING_1PhosphoSitePlus
S876LAERIsPKD2phosphoELM
S241SSSSSsSASSYPhosphoSitePlus
S212VRLGTsESLPCPhosphoSitePlus; RegPhos
S395HTTRKsSTTLRPhosphoSitePlus
S244SSSSAsSYTGRPhosphoSitePlus
T392SVRHTtRKSSTPhosphoSitePlus
T412YSNKDtLRKRHPHPhosphoSitePlus
S710KSFRRsVVGTPHPRD; phosphoELM; RegPhos
S353GVIPGsHSENAHPRD
T391QSVRHtTRKSSPhosphoSitePlus
S706IIGEKsFRRSVHPRD; phosphoELM; RegPhos
S876LAERIsVLautocatalysisRegPhos
S206LASGHsVRLGTPhosphoSitePlus; HPRD; phosphoELM
S876LAERIsVLPKD2RegPhos
S245SSSASsYTGRPPhosphoSitePlus
Y717VGTPAyLAPEVPkinasePhosphoSitePlus
Y717VGTPAyLAPEVHPRD; phosphoELM
S710KSFRRsVVGTPPkinasePhosphoSitePlus
S203STSLAsGHSVRPhosphoSitePlus; HPRD; phosphoELM
T199RRLSStSLASGPhosphoSitePlus; HPRD; phosphoELM
S238RPPSSsSSSSAPhosphoSitePlus
S225EELSRsTTELLPhosphoSitePlus
S239PPSSSsSSSASPhosphoSitePlus
S214LGTSEsLPCTAPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S200RLSSTsLASGHPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S355IPGSHsENALHPhosphoSitePlus
S375GKAQSsLGYIPPhosphoSitePlus; HPRD
S387MRVVQsVRHTTPhosphoSitePlus
Y438TTNRYyKEIPLPHPhosphoSitePlus
S706IIGEKsFRRSVPkinasePhosphoSitePlus
S197RKRRLsSTSLAPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T227LSRSTtELLPRPhosphoSitePlus
S876LAERIsPRKD2HPRD
Y246SSASSyTGRPIPhosphoSitePlus
S396TTRKSsTTLREPhosphoSitePlus; HPRD
S237RRPPSsSSSSSPhosphoSitePlus
S529PHRQAsLSISVPhosphoSitePlus
T398RKSSTtLREGWPHPhosphoSitePlus
T714RSVVGtPAYLAHPRD; phosphoELM
S198KRRLSsTSLASPhosphoSitePlus; HPRD; phosphoELM; RegPhos

Dephosphorylation site
KPCD2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000393978G870EHPIGastric Cancer17344846
ENSP00000291281G870EGreenman2007, HPIGastric Cancer17344846, 18428421
ENSP00000393978G848EHPILung Cancer17344846
ENSP00000291281G848EGreenman2007, HPILung Cancer16140923, 17344846, 18428421

Differential expressed protein
KPCD2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
KPCD2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PKD2_HUMANKPCD2_HUMANkinase -> substrateRegPhos
KPCD2_HUMANKPCD2_HUMANkinase -> substrateHPRD
KPCD2_HUMANHDAC7_HUMANkinase -> substrateNetPath
PXK_HUMANKPCD2_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANKPCD2_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KPCD2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0033138positive regulation of peptidyl-serine phosphorylaIGIbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIMPbiological_process
GO:0070374positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0048010vascular endothelial growth factor receptor signalIMPbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0004697protein kinase C activityIEAmolecular_function
GO:2001028positive regulation of endothelial cell chemotaxisIMPbiological_process
GO:0032743positive regulation of interleukin-2 productionISSbiological_process
GO:0061154endothelial tube morphogenesisTASbiological_process
GO:0007155cell adhesionIEAbiological_process
GO:0006468protein phosphorylationNASbiological_process
GO:0045785positive regulation of cell adhesionIMPbiological_process
GO:0018105peptidyl-serine phosphorylationIDAbiological_process
GO:0004672protein kinase activityIDAmolecular_function
GO:0050862positive regulation of T cell receptor signaling pIEAbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0008219cell deathIMPbiological_process
GO:0032793positive regulation of CREB transcription factor aIGIbiological_process
GO:0032743positive regulation of interleukin-2 productionIEAbiological_process
GO:0030949positive regulation of vascular endothelial growthIMPbiological_process
GO:0032757positive regulation of interleukin-8 productionIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0035924cellular response to vascular endothelial growth fIMPbiological_process
GO:0043536positive regulation of blood vessel endothelial ceIMPbiological_process
GO:0050862positive regulation of T cell receptor signaling pISSbiological_process
GO:0005622intracellularNAScellular_component
GO:0005634nucleusIDAcellular_component
GO:0001938positive regulation of endothelial cell proliferatIMPbiological_process
GO:1901727positive regulation of histone deacetylase activitIGIbiological_process
GO:0045766positive regulation of angiogenesisIMPbiological_process
GO:0045743positive regulation of fibroblast growth factor reIMPbiological_process
GO:0005543phospholipid bindingIEAmolecular_function
GO:0035556intracellular signal transductionNASbiological_process
GO:0005794Golgi apparatusIEAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0070374positive regulation of ERK1 and ERK2 cascadeISSbiological_process
GO:0038033positive regulation of endothelial cell chemotaxisIMPbiological_process
GO:0004674protein serine/threonine kinase activityNASmolecular_function
GO:0010595positive regulation of endothelial cell migrationIMPbiological_process
GO:0050852T cell receptor signaling pathwayIDAbiological_process
GO:0005524ATP bindingNASmolecular_function
GO:0051091positive regulation of sequence-specific DNA bindiIMPbiological_process
GO:2000573positive regulation of DNA biosynthetic processIEAbiological_process
GO:0010740positive regulation of intracellular protein kinasIMPbiological_process
GO:0046777protein autophosphorylationIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:2000573positive regulation of DNA biosynthetic processISSbiological_process
GO:0007243intracellular protein kinase cascadeIMPbiological_process