| UniProt/SwissProt ID: | KLF5_HUMAN |
| Description: | Kruppel-like factor 5 (intestinal) [Source:HGNC Symbol;Acc:6349] |
| Location: | chr13 q22.1 |
| Node attribute: | substrate; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S153 | TGLYKsQRPCV | PKCd | RegPhos |
| S153 | TGLYKsQRPCV | PhosphoSitePlus | |
| S153 | TGLYKsQRPCV | PKC_group | phosphoELM; RegPhos |
| S153 | TGLYKsQRPCV | PRKCD | HPRD |
| S116 | KYRRDsASVVD | HPRD | |
| S441 | GVCNRsFSRSD | zf-H2C2_2 | PhosphoSitePlus |
| Y377 | IHYCDyPGCTK | PhosphoSitePlus | |
| T396 | KAHLRtHTGEK | zf-H2C2_2 | PhosphoSitePlus |
| S303 | TYFPPsPPSSE | PhosphoSitePlus | |
| T346 | PNLPTtLPVNS | PhosphoSitePlus | |
| S441 | GVCNRsFSRSD | HPRD | |
| S443 | CNRSFsRSDHL | zf-H2C2_2 | PhosphoSitePlus |
| T398 | HLRTHtGEKPY | zf-H2C2_2 | PhosphoSitePlus |
| Dephosphorylation site |
| KLF5_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000366915 | H389N | COSMIC | Pancreatic Cancer | ENSP00000366915 | P301S | HPI | Colorectal Cancer | 16959974 | ENSP00000366915 | R114Q | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000366915 | M281I | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000366915 | P301S | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 | ENSP00000366915 | M281I | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| KLF5_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| KLF5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCD_HUMAN | KLF5_HUMAN | kinase -> substrate | HPRD |
| SP1_HUMAN | KLF5_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KLF5_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0001525 | angiogenesis | IEA | biological_process |
| GO:0043231 | intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0030033 | microvillus assembly | IEA | biological_process |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |