Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KLF4_HUMAN
Description:Kruppel-like factor 4 (gut) [Source:HGNC Symbol;Acc:6348]
Location:chr9 q31.2
Node attribute:TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T316LPSRTtPTLGLHPRD
S445TYTKSsHLKAHPhosphoSitePlus
S254SVSKGsPDGSHPhosphoSitePlus; HPRD
S240SPSVIsVSKGSphosphoELM
S258GSPDGsHPVVVPhosphoSitePlus
T455HLRTHtGEKPYzf-C2H2PhosphoSitePlus
S236LKASLsAPGSEHPRD
S444KTYTKsSHLKAPhosphoSitePlus
S244GSEYGsPSVISPhosphoSitePlus; HPRD
S327EEVLSsRDCHPPhosphoSitePlus
T453KAHLRtHTGEKzf-C2H2PhosphoSitePlus

Dephosphorylation site
KLF4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000363804R383TBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
KLF4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
KLF4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KLF4_HUMANHBB_HUMANTF -> target geneTRANSFAC
KLF4_HUMANCDN1A_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KLF4_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008270zinc ion bindingNASmolecular_function
GO:0044212transcription regulatory region DNA bindingIEAmolecular_function
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0048730epidermis morphogenesisIEAbiological_process
GO:0009913epidermal cell differentiationIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorNASmolecular_function
GO:0000790nuclear chromatinIDAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0045595regulation of cell differentiationIEAbiological_process
GO:0051247positive regulation of protein metabolic processIGIbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0014740negative regulation of muscle hyperplasiaIEAbiological_process
GO:0051898negative regulation of protein kinase B signaling IEAbiological_process
GO:0003690double-stranded DNA bindingIEAmolecular_function
GO:0019827stem cell maintenanceIEAbiological_process
GO:0001190RNA polymerase II transcription factor binding traIDAmolecular_function
GO:0007500mesodermal cell fate determinationTASbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:2000342negative regulation of chemokine (C-X-C motif) ligIDAbiological_process
GO:0060761negative regulation of response to cytokine stimulIDAbiological_process
GO:0008134transcription factor bindingIEAmolecular_function
GO:0005667transcription factor complexIEAcellular_component
GO:0000987core promoter proximal region sequence-specific DNIDAmolecular_function
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0045595regulation of cell differentiationISSbiological_process
GO:0035014phosphatidylinositol 3-kinase regulator activityIEAmolecular_function
GO:0001085RNA polymerase II transcription factor bindingIEAmolecular_function
GO:0034115negative regulation of heterotypic cell-cell adhesIDAbiological_process
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0001010sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0032088negative regulation of NF-kappaB transcription facIDAbiological_process
GO:0046985positive regulation of hemoglobin biosynthetic proIMPbiological_process
GO:0006366transcription from RNA polymerase II promoterISSbiological_process
GO:0032526response to retinoic acidIEAbiological_process
GO:0006366transcription from RNA polymerase II promoterIEAbiological_process
GO:0042221response to chemical stimulusIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0050728negative regulation of inflammatory responseTASbiological_process
GO:0000785chromatinIEAcellular_component
GO:0045444fat cell differentiationIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyISSbiological_process
GO:0071363cellular response to growth factor stimulusIDAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0090051negative regulation of cell migration involved in IDAbiological_process
GO:0014067negative regulation of phosphatidylinositol 3-kinaIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenISSbiological_process
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0070373negative regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0035166post-embryonic hemopoiesisIMPbiological_process
GO:0031077post-embryonic camera-type eye developmentIEAbiological_process
GO:0008285negative regulation of cell proliferationTASbiological_process
GO:0048662negative regulation of smooth muscle cell proliferIEAbiological_process
GO:0030154cell differentiationIEAbiological_process
GO:0043154negative regulation of cysteine-type endopeptidaseIDAbiological_process
GO:0001077RNA polymerase II core promoter proximal region seIEAmolecular_function
GO:0045415negative regulation of interleukin-8 biosynthetic IDAbiological_process
GO:0043551regulation of phosphatidylinositol 3-kinase activiIEAbiological_process