| UniProt/SwissProt ID: | KC1AL_HUMAN |
| Description: | casein kinase 1, alpha 1-like [Source:HGNC Symbol;Acc:20289] |
| Location: | chr13 q13.3 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S206 | RDDMEsLGYVF | Pkinase_CK1 | PhosphoSitePlus |
| Y59 | HPQLLyESKLY | Pkinase_CK1 | PhosphoSitePlus |
| Y294 | NHQYDyTFDWT | PhosphoSitePlus | |
| Y209 | MESLGyVFMYF | Pkinase_CK1 | PhosphoSitePlus |
| T287 | RILFRtLNHQY | PhosphoSitePlus | |
| T228 | GLRAMtKKQKY | Pkinase_CK1 | PhosphoSitePlus |
| Y292 | TLNHQyDYTFD | PhosphoSitePlus | |
| Y213 | GYVFMyFNRTS | Pkinase_CK1 | PhosphoSitePlus |
| T184 | KHLIGtVRYAS | Pkinase_CK1 | PhosphoSitePlus |
| Dephosphorylation site |
| KC1AL_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000369126 | R21Q | BIOMART, HPI | Colorectal Cancer | 21930507, 21930502, 16959974 | ENSP00000369126 | E10K | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000369126 | H75L | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000369126 | R21Q | Sjoblom2006 | Intestines Cancer | 16959974, 21930507, 21930502 |
| Differential expressed protein |
| KC1AL_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| KC1AL_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KC1AL_HUMAN | GLI1_HUMAN | kinase -> substrate | KEGG |
| KC1AL_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04340 | Hedgehog signaling pathway |
| hsa04310 | Wnt signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0030529 | ribonucleoprotein complex | IEA | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0016055 | Wnt receptor signaling pathway | IEA | biological_process |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0000902 | cell morphogenesis | IEA | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |