Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KAD2_HUMAN
Description:adenylate kinase 2 [Source:HGNC Symbol;Acc:362]
Location:chr1 p35.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y12AAEPEyPKGIRPhosphoSitePlus
Y201PLIEYyRKRGIADKPhosphoSitePlus
Y190IRLQAyHTQTTADKPhosphoSitePlus
Y200TPLIEyYRKRGADKPhosphoSitePlus
T215IDASQtPDVVFHPRD
S56RAMVAsGSELGHPRD
S208KRGIHsAIDASHPRD

Dephosphorylation site
KAD2_HUMAN do not have dephosphorylation site.

Mutation site
KAD2_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000346921Breast CancerNormal vs. Cancercell lineUp214997480
ENSP00000346921Breast CancerTreatment (tamoxifen-sensitive vs. tamoxifen-resistant)tissueDown0.4919329653
ENSP00000346921LeukemiaCancer vs. Cancer (subtype)tissueUp15501966

Hyperphosphorylation site
KAD2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KC1E_HUMANKAD2_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANKAD2_HUMANkinase -> substrateRobert H Newman (2013)
MP2K7_HUMANKAD2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KAD2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0046060dATP metabolic processIEAbiological_process
GO:0001889liver developmentIEAbiological_process
GO:0005758mitochondrial intermembrane spaceIEAcellular_component
GO:0007420brain developmentIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005743mitochondrial inner membraneIEAcellular_component
GO:0046939nucleotide phosphorylationIEAbiological_process
GO:0006139nucleobase-containing compound metabolic processIEAbiological_process
GO:0005758mitochondrial intermembrane spaceTAScellular_component
GO:0006119oxidative phosphorylationIEAbiological_process
GO:0055086nucleobase-containing small molecule metabolic proTASbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0036126sperm flagellumIEAcellular_component
GO:0015949nucleobase-containing small molecule interconversiTASbiological_process
GO:0005829cytosolIEAcellular_component
GO:0005739mitochondrionIEAcellular_component
GO:0019205nucleobase-containing compound kinase activityIEAmolecular_function
GO:0006172ADP biosynthetic processIEAbiological_process
GO:0046034ATP metabolic processIEAbiological_process
GO:0004017adenylate kinase activityIEAmolecular_function
GO:0016776phosphotransferase activity, phosphate group as acIEAmolecular_function
GO:0046033AMP metabolic processIEAbiological_process
GO:0019201nucleotide kinase activityIEAmolecular_function
GO:0097226sperm mitochondrial sheathIEAcellular_component
GO:0097066response to thyroid hormone stimulusIEAbiological_process


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