| UniProt/SwissProt ID: | K1C16_HUMAN |
| Description: | keratin 16 [Source:HGNC Symbol;Acc:6423] |
| Location: | chr17 q21.2 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y417 | QEIATyRRLLE | Filament | PhosphoSitePlus |
| Y438 | ASGQSySSREV | PhosphoSitePlus | |
| T204 | ADDFRtKYEHE | Filament; Myosin_tail_1; | PhosphoSitePlus |
| Y153 | KIRDWyQRQRP | Filament | PhosphoSitePlus |
| S463 | ILKEQsSSSFS | PhosphoSitePlus | |
| S17 | SSMKGsCGIGG | PhosphoSitePlus | |
| S13 | FTSSSsMKGSC | PhosphoSitePlus | |
| Y250 | KEELAyLRKNH | Filament; Myosin_tail_1; | PhosphoSitePlus |
| T45 | CRAPStYGGGL | PhosphoSitePlus | |
| S321 | NKEVAsNSELV | Filament; COG2; DUF1664; | PhosphoSitePlus |
| S329 | ELVQSsRSEVT | Filament; COG2; DUF1664; | PhosphoSitePlus |
| T235 | LTLARtDLEMQ | HPRD | |
| S44 | SCRAPsTYGGG | PhosphoSitePlus | |
| S28 | GIGGGsSRISS | PhosphoSitePlus | |
| Y46 | RAPSTyGGGLS | PhosphoSitePlus | |
| S464 | LKEQSsSSFSQ | PhosphoSitePlus | |
| S33 | SSRISsVLAGG | PhosphoSitePlus | |
| Y206 | DFRTKyEHELA | Filament; Myosin_tail_1; | PhosphoSitePlus |
| S12 | QFTSSsSMKGS | PhosphoSitePlus | |
| Y131 | DRLASyLDKVR | Filament | PhosphoSitePlus |
| S39 | VLAGGsCRAPS | PhosphoSitePlus | |
| Y167 | KDYSPyFKTIE | Filament | PhosphoSitePlus |
| S32 | GSSRIsSVLAG | PhosphoSitePlus | |
| S54 | GLSVSsRFSSG | PhosphoSitePlus | |
| S130 | NDRLAsYLDKV | Filament | PhosphoSitePlus |
| T215 | LALRQtVEADV | Filament; Myosin_tail_1; | PhosphoSitePlus |
| T9 | CSRQFtSSSSM | PhosphoSitePlus | |
| Dephosphorylation site |
| K1C16_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000301653 | M296K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000301653 | *474G | COSMIC | Ovarian Cancer | 21720365 | ENSP00000301653 | T408M | COSMIC | Head and Neck Cancer | 21984974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000301653 | Oral Cancer | Normal vs. Cancer | tissue | Up | 27 | 19297561 | ENSP00000301653 | Hepatocellular Carcinoma | Cancer vs. Cancer (HCC vs. HuCCA) | cell line | Up | 20069059 | ENSP00000301653 | Gastric Cancer | Normal vs. Cancer | tissue | Up | 4.3 | 19330469 | ENSP00000301653 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.1 | 20198662 | ENSP00000301653 | Uterine Cancer | Normal vs. Cancer | tissue | Up | 16051329 | ENSP00000301653 | Uterine Cancer | Normal vs. Cancer | tissue | Up | 19771267 |
| Hyperphosphorylation site |
| K1C16_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FOS_HUMAN | K1C16_HUMAN | TF -> target gene | TRANSFAC |
| SP1_HUMAN | K1C16_HUMAN | TF -> target gene | TRANSFAC |
| JUN_HUMAN | K1C16_HUMAN | TF -> target gene | TRANSFAC |
| SP3_HUMAN | K1C16_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| K1C16_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007010 | cytoskeleton organization | NAS | biological_process |
| GO:0005200 | structural constituent of cytoskeleton | IEA | molecular_function |
| GO:0045104 | intermediate filament cytoskeleton organization | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005882 | intermediate filament | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005882 | intermediate filament | NAS | cellular_component |
| GO:0005198 | structural molecule activity | IEA | molecular_function |
| GO:0008283 | cell proliferation | TAS | biological_process |
| GO:0008544 | epidermis development | TAS | biological_process |
| GO:0005200 | structural constituent of cytoskeleton | NAS | molecular_function |