Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:K1C16_HUMAN
Description:keratin 16 [Source:HGNC Symbol;Acc:6423]
Location:chr17 q21.2
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y417QEIATyRRLLEFilamentPhosphoSitePlus
Y438ASGQSySSREVPhosphoSitePlus
T204ADDFRtKYEHEFilament; Myosin_tail_1; PhosphoSitePlus
Y153KIRDWyQRQRPFilamentPhosphoSitePlus
S463ILKEQsSSSFSPhosphoSitePlus
S17SSMKGsCGIGGPhosphoSitePlus
S13FTSSSsMKGSCPhosphoSitePlus
Y250KEELAyLRKNHFilament; Myosin_tail_1; PhosphoSitePlus
T45CRAPStYGGGLPhosphoSitePlus
S321NKEVAsNSELVFilament; COG2; DUF1664; PhosphoSitePlus
S329ELVQSsRSEVTFilament; COG2; DUF1664; PhosphoSitePlus
T235LTLARtDLEMQHPRD
S44SCRAPsTYGGGPhosphoSitePlus
S28GIGGGsSRISSPhosphoSitePlus
Y46RAPSTyGGGLSPhosphoSitePlus
S464LKEQSsSSFSQPhosphoSitePlus
S33SSRISsVLAGGPhosphoSitePlus
Y206DFRTKyEHELAFilament; Myosin_tail_1; PhosphoSitePlus
S12QFTSSsSMKGSPhosphoSitePlus
Y131DRLASyLDKVRFilamentPhosphoSitePlus
S39VLAGGsCRAPSPhosphoSitePlus
Y167KDYSPyFKTIEFilamentPhosphoSitePlus
S32GSSRIsSVLAGPhosphoSitePlus
S54GLSVSsRFSSGPhosphoSitePlus
S130NDRLAsYLDKVFilamentPhosphoSitePlus
T215LALRQtVEADVFilament; Myosin_tail_1; PhosphoSitePlus
T9CSRQFtSSSSMPhosphoSitePlus

Dephosphorylation site
K1C16_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000301653M296KBIOMARTBreast Cancer21930507, 21930502
ENSP00000301653*474GCOSMICOvarian Cancer21720365
ENSP00000301653T408MCOSMICHead and Neck Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000301653Oral CancerNormal vs. CancertissueUp2719297561
ENSP00000301653Hepatocellular CarcinomaCancer vs. Cancer (HCC vs. HuCCA)cell lineUp20069059
ENSP00000301653Gastric CancerNormal vs. CancertissueUp4.319330469
ENSP00000301653Breast CancerNormal vs. Cancercell lineDown0.120198662
ENSP00000301653Uterine CancerNormal vs. CancertissueUp16051329
ENSP00000301653Uterine CancerNormal vs. CancertissueUp19771267

Hyperphosphorylation site
K1C16_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FOS_HUMANK1C16_HUMANTF -> target geneTRANSFAC
SP1_HUMANK1C16_HUMANTF -> target geneTRANSFAC
JUN_HUMANK1C16_HUMANTF -> target geneTRANSFAC
SP3_HUMANK1C16_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
K1C16_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007010cytoskeleton organizationNASbiological_process
GO:0005200structural constituent of cytoskeletonIEAmolecular_function
GO:0045104intermediate filament cytoskeleton organizationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005882intermediate filamentIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005882intermediate filamentNAScellular_component
GO:0005198structural molecule activityIEAmolecular_function
GO:0008283cell proliferationTASbiological_process
GO:0008544epidermis developmentTASbiological_process
GO:0005200structural constituent of cytoskeletonNASmolecular_function


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23