Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:JAM1_HUMAN
Description:Junctional adhesion molecule A [Source:UniProtKB/Swiss-Prot;Acc:Q9Y624]
Location:chr1 q23.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y107EDTGTyTCMVSV-setPhosphoSitePlus
S287QPSARsEGEFKPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S133VLVPPsKPTVNIg_2PhosphoSitePlus
S275KKGTSsKKVIYHPRD; phosphoELM
S141TVNIPsSATIGHPRD
T92VTFLPtGITFKPRKCAHPRD
T95LPTGItFKSVTHPRD
S284IYSQPsARSEGPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T92VTFLPtGITFKPKCaRegPhos
T100TFKSVtREDTGV-setPhosphoSitePlus
S98GITFKsVTREDV-setPhosphoSitePlus
T136PPSKPtVNIPSHPRD
S34VTVHSsEPEVRCK2a1RegPhos
S281KKVIYsQPSARPhosphoSitePlus; HPRD; phosphoELM
S142VNIPSsATIGNHPRD
T70DQGDTtRLVCYPKCaRegPhos
Y280SKKVIySQPSAPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S133VLVPPsKPTVNHPRD
S296FKQTSsFHPRD
T144IPSSAtIGNRAHPRD
T70DQGDTtRLVCYPRKCAHPRD
S34VTVHSsEPEVRCK2a1-rsRegPhos
S34VTVHSsEPEVRCSNK2A1HPRD
T273RTKKGtSSKKVPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
JAM1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000357005D200HBIOMARTBreast Cancer21930507, 21930502
ENSP00000289779G120WCOSMICOvarian Cancer21720365
ENSP00000337141D200HBIOMARTBreast Cancer21930507, 21930502
ENSP00000289779D200HBIOMARTBreast Cancer21930507, 21930502
ENSP00000289779L14FCOSMICOvarian Cancer21720365

Differential expressed protein
JAM1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y280TSSKKVIySQPSARScholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANJAM1_HUMANkinase -> substrateRegPhos
KPCA_HUMANJAM1_HUMANkinase -> substrateHPRD
CSK21_HUMANJAM1_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04514Cell adhesion molecules (CAMs)
hsa05120Epithelial cell signaling in Helicobacter pylori i
hsa04670Leukocyte transendothelial migration
hsa04530Tight junction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0050900leukocyte migrationTASbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0019048virus-host interactionIEAbiological_process
GO:0005911cell-cell junctionTAScellular_component
GO:0045216cell-cell junction organizationTASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0006954inflammatory responseTASbiological_process
GO:0030054cell junctionTAScellular_component
GO:0030855epithelial cell differentiationIEAbiological_process
GO:0005923tight junctionIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0007155cell adhesionIEAbiological_process
GO:0007179transforming growth factor beta receptor signalingTASbiological_process
GO:0070830tight junction assemblyTASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0034329cell junction assemblyTASbiological_process


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