| UniProt/SwissProt ID: | ITAX_HUMAN |
| Description: | integrin, alpha X (complement component 3 receptor 4 subunit) [Source:HGNC Symbol;Acc:6152] |
| Location: | chr16 p11.2 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S673 | SRDLQsSVTLD | PhosphoSitePlus | |
| S668 | KNLLGsRDLQS | PhosphoSitePlus | |
| S674 | RDLQSsVTLDL | PhosphoSitePlus | |
| Dephosphorylation site |
| ITAX_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000268296 | W501* | COSMIC | Skin Cancer | 21984974 | ENSP00000268296 | A412V | COSMIC | Pancreatic Cancer | 21252315 | ENSP00000268296 | K535Q | COSMIC | Ovarian Cancer | 21720365 | ENSP00000268296 | K535Q | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000268296 | S885F | COSMIC | Skin Cancer | 21984974 | ENSP00000268296 | A176V | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000268296 | L1051F | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| ITAX_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ITAX_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| JUN_HUMAN | ITAX_HUMAN | TF -> target gene | TRANSFAC |
| ETS1_HUMAN | ITAX_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| ITAX_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007155 | cell adhesion | IEA | biological_process |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0007229 | integrin-mediated signaling pathway | IEA | biological_process |
| GO:0051607 | defense response to virus | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0009887 | organ morphogenesis | TAS | biological_process |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0050900 | leukocyte migration | TAS | biological_process |
| GO:0008305 | integrin complex | IEA | cellular_component |
| GO:0004872 | receptor activity | TAS | molecular_function |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0009897 | external side of plasma membrane | IEA | cellular_component |