Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ITAM_HUMAN
Description:integrin, alpha M (complement component 3 receptor 3 subunit) [Source:HGNC Symbol;Acc:6149]
Location:chr16 p11.2
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y676QSVVTyDLALDIntegrin_alpha2PhosphoSitePlus
T930VYMVVtSHGVSIntegrin_alpha2PhosphoSitePlus
S1142YKDMMsEGGPPIntegrin_alphaPhosphoSitePlus
S931YMVVTsHGVSTIntegrin_alpha2PhosphoSitePlus
S574QRIAGsKLSPRPhosphoSitePlus; HPRD
T805FNVTVtVRNDGIntegrin_alpha2PhosphoSitePlus
S577AGSKLsPRLQYPhosphoSitePlus; HPRD

Dephosphorylation site
ITAM_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000287497K646NCOSMICRenal Cancer20054297
ENSP00000287497N326DBIOMARTHepatocellular Carcinoma21930507, 21930502

Differential expressed protein
ITAM_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ITAM_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SP1_HUMANITAM_HUMANTF -> target geneTRANSFAC
SPI1_HUMANITAM_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
ITAM_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0009897external side of plasma membraneIEAcellular_component
GO:0030593neutrophil chemotaxisIEAbiological_process
GO:0001948glycoprotein bindingIPImolecular_function
GO:0007155cell adhesionIEAbiological_process
GO:0043395heparan sulfate proteoglycan bindingIEAmolecular_function
GO:0008305integrin complexIEAcellular_component
GO:0007229integrin-mediated signaling pathwayIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0007155cell adhesionTASbiological_process
GO:0008201heparin bindingIEAmolecular_function
GO:0007159leukocyte cell-cell adhesionIEAbiological_process
GO:0050900leukocyte migrationTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0007596blood coagulationTASbiological_process
GO:0001846opsonin bindingIEAmolecular_function
GO:0046872metal ion bindingIEAmolecular_function
GO:0016337cell-cell adhesionIEAbiological_process
GO:0050798activated T cell proliferationIEAbiological_process
GO:0009986cell surfaceIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0014005microglia developmentIEAbiological_process
GO:0045123cellular extravasationIEAbiological_process
GO:0005515protein bindingIPImolecular_function


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