| UniProt/SwissProt ID: | ITA4_HUMAN |
| Description: | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) [Source:HGNC Symbol;Acc:6140] |
| Location: | chr2 q31.3 |
| Node attribute: | substrate; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S1027 | ENRRDsWSYIN | RegPhos; SysPTM | |
| Y1024 | RDSWSyINSKS | PhosphoSitePlus | |
| S1021 | ENRRDsWSYIN | PRKACA | HPRD |
| S1021 | ENRRDsWSYIN | PhosphoSitePlus | |
| S1027 | ENRRDsWSYIN | PKACa | RegPhos; SysPTM |
| S634 | ADLQVsAKIGF | Integrin_alpha2 | PhosphoSitePlus |
| S924 | LEGRPsILEMD | PhosphoSitePlus | |
| S1027 | ENRRDsWSYIN | PKA_group | phosphoELM; RegPhos; SysPTM |
| S1029 | YINSKsNDD__ | PhosphoSitePlus | |
| S1011 | KRQYKsILQEE | Integrin_alpha | PhosphoSitePlus |
| S1023 | RRDSWsYINSK | PhosphoSitePlus | |
| Dephosphorylation site |
| ITA4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000380227 | K363N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000380227 | P11L | COSMIC | Lung Cancer | ENSP00000380227 | P642H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000380227 | P946Q | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000380227 | G490* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000380227 | G431V | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000380227 | G490* | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000380227 | K363N | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000380227 | P642H | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| ITA4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ITA4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | ITA4_HUMAN | kinase -> substrate | HPRD |
| ZAGL2_HUMAN | ITA4_HUMAN | kinase -> substrate | RegPhos |
| P53_HUMAN | ITA4_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04810 | Regulation of actin cytoskeleton |
| hsa04512 | ECM-receptor interaction |
| hsa04640 | Hematopoietic cell lineage |
| hsa05140 | Leishmaniasis |
| hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (A |
| hsa04510 | Focal adhesion |
| hsa05410 | Hypertrophic cardiomyopathy (HCM) |
| hsa04670 | Leukocyte transendothelial migration |
| hsa04514 | Cell adhesion molecules (CAMs) |
| hsa05414 | Dilated cardiomyopathy |
| hsa04672 | Intestinal immune network for IgA production |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007155 | cell adhesion | IEA | biological_process |
| GO:0007157 | heterophilic cell-cell adhesion | IEA | biological_process |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0007229 | integrin-mediated signaling pathway | IEA | biological_process |
| GO:0050900 | leukocyte migration | TAS | biological_process |
| GO:0001968 | fibronectin binding | IEA | molecular_function |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0009897 | external side of plasma membrane | IEA | cellular_component |
| GO:0016477 | cell migration | IEA | biological_process |
| GO:0030183 | B cell differentiation | IC | biological_process |
| GO:0001974 | blood vessel remodeling | IEA | biological_process |
| GO:0007507 | heart development | IEA | biological_process |
| GO:0060710 | chorio-allantoic fusion | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0060324 | face development | IEA | biological_process |
| GO:0009986 | cell surface | IDA | cellular_component |
| GO:0050776 | regulation of immune response | TAS | biological_process |
| GO:0007159 | leukocyte cell-cell adhesion | IEA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0008305 | integrin complex | IEA | cellular_component |