Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ITA4_HUMAN
Description:integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) [Source:HGNC Symbol;Acc:6140]
Location:chr2 q31.3
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1027ENRRDsWSYINRegPhos; SysPTM
Y1024RDSWSyINSKSPhosphoSitePlus
S1021ENRRDsWSYINPRKACAHPRD
S1021ENRRDsWSYINPhosphoSitePlus
S1027ENRRDsWSYINPKACaRegPhos; SysPTM
S634ADLQVsAKIGFIntegrin_alpha2PhosphoSitePlus
S924LEGRPsILEMDPhosphoSitePlus
S1027ENRRDsWSYINPKA_groupphosphoELM; RegPhos; SysPTM
S1029YINSKsNDD__PhosphoSitePlus
S1011KRQYKsILQEEIntegrin_alphaPhosphoSitePlus
S1023RRDSWsYINSKPhosphoSitePlus

Dephosphorylation site
ITA4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000380227K363NCOSMICOvarian Cancer21720365
ENSP00000380227P11LCOSMICLung Cancer
ENSP00000380227P642HCOSMICOvarian Cancer21720365
ENSP00000380227P946QCOSMICCentral Nervous System Neoplasms18772396
ENSP00000380227G490*COSMICOvarian Cancer21720365
ENSP00000380227G431VCOSMICHead and Neck Cancer21798893
ENSP00000380227G490*TCGAOvarian Cancer21720365, 18772890
ENSP00000380227K363NTCGAOvarian Cancer21720365, 18772890
ENSP00000380227P642HTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
ITA4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ITA4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANITA4_HUMANkinase -> substrateHPRD
ZAGL2_HUMANITA4_HUMANkinase -> substrateRegPhos
P53_HUMANITA4_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04810Regulation of actin cytoskeleton
hsa04512ECM-receptor interaction
hsa04640Hematopoietic cell lineage
hsa05140Leishmaniasis
hsa05412Arrhythmogenic right ventricular cardiomyopathy (A
hsa04510Focal adhesion
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa04670Leukocyte transendothelial migration
hsa04514Cell adhesion molecules (CAMs)
hsa05414Dilated cardiomyopathy
hsa04672Intestinal immune network for IgA production

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007155cell adhesionIEAbiological_process
GO:0007157heterophilic cell-cell adhesionIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0007229integrin-mediated signaling pathwayIEAbiological_process
GO:0050900leukocyte migrationTASbiological_process
GO:0001968fibronectin bindingIEAmolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0009897external side of plasma membraneIEAcellular_component
GO:0016477cell migrationIEAbiological_process
GO:0030183B cell differentiationICbiological_process
GO:0001974blood vessel remodelingIEAbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0060710chorio-allantoic fusionIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0060324face developmentIEAbiological_process
GO:0009986cell surfaceIDAcellular_component
GO:0050776regulation of immune responseTASbiological_process
GO:0007159leukocyte cell-cell adhesionIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0008305integrin complexIEAcellular_component


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