| UniProt/SwissProt ID: | ISK1_HUMAN |
| Description: | serine peptidase inhibitor, Kazal type 1 [Source:HGNC Symbol;Acc:11244] |
| Location: | chr5 q32 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S10 | GIFLLsALALL | HPRD | |
| S16 | ALALLsLSGNT | HPRD | |
| S18 | ALLSLsGNTGA | HPRD | |
| Dephosphorylation site |
| ISK1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| ISK1_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000296695 | Neoplasms by Histologic Type | Treatment (none vs. SB203580 treatment 3 hour) | cell line | Down | 0.6 | 15169874 |
| Hyperphosphorylation site |
| ISK1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CEBPB_HUMAN | ISK1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| ISK1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005576 | extracellular region | IEA | cellular_component |
| GO:0010951 | negative regulation of endopeptidase activity | TAS | biological_process |
| GO:0004867 | serine-type endopeptidase inhibitor activity | IEA | molecular_function |
| GO:0004866 | endopeptidase inhibitor activity | TAS | molecular_function |