Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ISK1_HUMAN
Description:serine peptidase inhibitor, Kazal type 1 [Source:HGNC Symbol;Acc:11244]
Location:chr5 q32
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S10GIFLLsALALLHPRD
S16ALALLsLSGNTHPRD
S18ALLSLsGNTGAHPRD

Dephosphorylation site
ISK1_HUMAN do not have dephosphorylation site.

Mutation site
ISK1_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000296695Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 3 hour)cell lineDown0.615169874

Hyperphosphorylation site
ISK1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CEBPB_HUMANISK1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
ISK1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0005576extracellular regionIEAcellular_component
GO:0010951negative regulation of endopeptidase activityTASbiological_process
GO:0004867serine-type endopeptidase inhibitor activityIEAmolecular_function
GO:0004866endopeptidase inhibitor activityTASmolecular_function


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