| UniProt/SwissProt ID: | IRS4_HUMAN |
| Description: | insulin receptor substrate 4 [Source:HGNC Symbol;Acc:6128] |
| Location: | chrX q22.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T1237 | DNDDDtHVRMD | HPRD | |
| Y111 | PARLEyYENAR | PH | PhosphoSitePlus |
| S1231 | PEREDsDNDDD | HPRD | |
| S877 | SPSKPsDHEPP | HPRD | |
| S919 | EADSSsDYVNM | PhosphoSitePlus | |
| S714 | TPLVSsSDYMP | PhosphoSitePlus | |
| Y1038 | DSAIRyDAETG | PhosphoSitePlus | |
| Y743 | EDSRGyMMMFP | PhosphoSitePlus; HPRD | |
| T938 | TPAPStQGLPD | PhosphoSitePlus | |
| S874 | DGGSPsKPSDH | HPRD | |
| S865 | GEGSFsKPGDG | HPRD | |
| Y717 | VSSSDyMPMAP | PhosphoSitePlus; HPRD | |
| S64 | ATGSRsDSESE | HPRD | |
| Y291 | GHSEQyFFLEV | IRS | PhosphoSitePlus |
| S872 | PGDGGsPSKPS | HPRD | |
| S715 | PLVSSsDYMPM | PhosphoSitePlus | |
| T620 | YFGKLtQSKQQ | PhosphoSitePlus | |
| S68 | RSDSEsEEEDL | HPRD | |
| Y1046 | ETGRIyVVDPF | HPRD | |
| Y921 | DSSSDyVNMDF | PhosphoSitePlus | |
| S66 | GSRSDsESEEE | HPRD | |
| T7 | ASCSFtRDQAT | PhosphoSitePlus | |
| Y808 | KSWSSyFSLPN | PhosphoSitePlus | |
| S570 | GGGHGsGGGQG | PhosphoSitePlus | |
| S859 | AASKPsGEGSF | HPRD | |
| Y779 | DSESDyMFMAP | PhosphoSitePlus; HPRD | |
| S1107 | AFPTDsLERDL | HPRD | |
| T552 | RDGQGtAGGHG | PhosphoSitePlus | |
| S856 | PKDAAsKPSGE | HPRD | |
| Y700 | DEDDPyVPMRP | PhosphoSitePlus; HPRD | |
| S558 | AGGHGsGGGQR | PhosphoSitePlus | |
| Y828 | NDNSEyVPMLP | PhosphoSitePlus | |
| S826 | GQNDNsEYVPM | PhosphoSitePlus | |
| S622 | GKLTQsKQQQM | PhosphoSitePlus | |
| S588 | GGGKNsGGGKG | PhosphoSitePlus | |
| Dephosphorylation site |
| IRS4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000361202 | *1258K | COSMIC | Ovarian Cancer | 21720365 | ENSP00000361202 | A20V | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 | ENSP00000361202 | E70* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000361202 | E392K | COSMIC | Melanoma | 21499247 | ENSP00000361202 | G557R | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 | ENSP00000361202 | G215E | Sjoblom2006 | Intestines Cancer | 16959974 | ENSP00000361202 | V1047L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000361202 | G557R | HPI | Colorectal Cancer | 16959974 | ENSP00000361202 | P971L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000361202 | G215E | Sjoblom2006, COSMIC | Breast Cancer | 16959974 | ENSP00000361202 | G215E | HPI | Colorectal Cancer | 16959974 | ENSP00000361202 | A788T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000361202 | R731H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000361202 | D977H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000361202 | A20V | HPI | Colorectal Cancer | 16959974 |
| Differential expressed protein |
| IRS4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| IRS4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PP4C_HUMAN | IRS4_HUMAN | phosphatase -> substrate | NetPath |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04930 | Type II diabetes mellitus |
| hsa04910 | Insulin signaling pathway |
| hsa04920 | Adipocytokine signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005070 | SH3/SH2 adaptor activity | TAS | molecular_function |
| GO:0004871 | signal transducer activity | IEA | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0005158 | insulin receptor binding | IEA | molecular_function |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0005543 | phospholipid binding | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |