Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IRS4_HUMAN
Description:insulin receptor substrate 4 [Source:HGNC Symbol;Acc:6128]
Location:chrX q22.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T1237DNDDDtHVRMDHPRD
Y111PARLEyYENARPHPhosphoSitePlus
S1231PEREDsDNDDDHPRD
S877SPSKPsDHEPPHPRD
S919EADSSsDYVNMPhosphoSitePlus
S714TPLVSsSDYMPPhosphoSitePlus
Y1038DSAIRyDAETGPhosphoSitePlus
Y743EDSRGyMMMFPPhosphoSitePlus; HPRD
T938TPAPStQGLPDPhosphoSitePlus
S874DGGSPsKPSDHHPRD
S865GEGSFsKPGDGHPRD
Y717VSSSDyMPMAPPhosphoSitePlus; HPRD
S64ATGSRsDSESEHPRD
Y291GHSEQyFFLEVIRSPhosphoSitePlus
S872PGDGGsPSKPSHPRD
S715PLVSSsDYMPMPhosphoSitePlus
T620YFGKLtQSKQQPhosphoSitePlus
S68RSDSEsEEEDLHPRD
Y1046ETGRIyVVDPFHPRD
Y921DSSSDyVNMDFPhosphoSitePlus
S66GSRSDsESEEEHPRD
T7ASCSFtRDQATPhosphoSitePlus
Y808KSWSSyFSLPNPhosphoSitePlus
S570GGGHGsGGGQGPhosphoSitePlus
S859AASKPsGEGSFHPRD
Y779DSESDyMFMAPPhosphoSitePlus; HPRD
S1107AFPTDsLERDLHPRD
T552RDGQGtAGGHGPhosphoSitePlus
S856PKDAAsKPSGEHPRD
Y700DEDDPyVPMRPPhosphoSitePlus; HPRD
S558AGGHGsGGGQRPhosphoSitePlus
Y828NDNSEyVPMLPPhosphoSitePlus
S826GQNDNsEYVPMPhosphoSitePlus
S622GKLTQsKQQQMPhosphoSitePlus
S588GGGKNsGGGKGPhosphoSitePlus

Dephosphorylation site
IRS4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000361202*1258KCOSMICOvarian Cancer21720365
ENSP00000361202A20VSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000361202E70*COSMICOvarian Cancer21720365
ENSP00000361202E392KCOSMICMelanoma21499247
ENSP00000361202G557RSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000361202G215ESjoblom2006Intestines Cancer16959974
ENSP00000361202V1047LCOSMICOvarian Cancer21720365
ENSP00000361202G557RHPIColorectal Cancer16959974
ENSP00000361202P971LCOSMICOvarian Cancer21720365
ENSP00000361202G215ESjoblom2006, COSMICBreast Cancer16959974
ENSP00000361202G215EHPIColorectal Cancer16959974
ENSP00000361202A788TCOSMICOvarian Cancer21720365
ENSP00000361202R731HCOSMICOvarian Cancer21720365
ENSP00000361202D977HBIOMARTBreast Cancer21930507, 21930502
ENSP00000361202A20VHPIColorectal Cancer16959974

Differential expressed protein
IRS4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IRS4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PP4C_HUMANIRS4_HUMANphosphatase -> substrateNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04930Type II diabetes mellitus
hsa04910Insulin signaling pathway
hsa04920Adipocytokine signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005070SH3/SH2 adaptor activityTASmolecular_function
GO:0004871signal transducer activityIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0005158insulin receptor bindingIEAmolecular_function
GO:0007165signal transductionTASbiological_process
GO:0005543phospholipid bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23