Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IRS2_HUMAN
Description:insulin receptor substrate 2 [Source:HGNC Symbol;Acc:6126]
Location:chr13 q34
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y628VAYHPyPEDYGINSRHPRD; RegPhos
S506DEYGSsPGDLRPhosphoSitePlus
T776PSDAVtTGTPPPhosphoSitePlus
S1174PKRHNsASVENPhosphoSitePlus; HPRD; phosphoELM
T604TLMRAtFSGSAPhosphoSitePlus; HPRD
S432HSRSMsMPVAHPhosphoSitePlus
Y919KSPGEyINIDFINSRRegPhos
Y675CRSDDyMPMSPINSRRegPhos
T363SCRVRtASEGDPhosphoSitePlus; HPRD; phosphoELM
Y628VAYHPyPEDYGPhosphoSitePlus
T779AVTTGtPPDFFPhosphoSitePlus; HPRD; phosphoELM
S804PGCCYsSLPRSPhosphoSitePlus
T1156TFSSTtTVTPVPhosphoSitePlus
S1203DEPPTsPRQLQPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S515LRAFCsHRSNTPhosphoSitePlus
S560SYRRVsGDAAQPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y576LRKRTySLTTPPhosphoSitePlus
Y598ASLDEyTLMRAPhosphoSitePlus
S518FCSHRsNTPESPhosphoSitePlus; HPRD; phosphoELM
Y542GEFYGyMTMDRPhosphoSitePlus
T520SHRSNtPESIAPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S594QPSSAsLDEYTPhosphoSitePlus; HPRD; phosphoELM
S645HRSSSsNLGADPhosphoSitePlus
T350DSLAAtPPAAKPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S592VPQPSsASLDEHPRD
S976QRSPLsDYMNLHPRD
S740SSPEDsGYMRMPhosphoSitePlus
S903LPSLPsMHEYPPhosphoSitePlus
Y653GADDGyMPMTPINSRRegPhos
S1154SETFSsTTTVTPhosphoSitePlus
S608ATFSGsAGRLCPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y75PPRLEyYESEKHPRD; phosphoELM
S1149RRRHSsETFSSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S730GGYKAsSPAESPhosphoSitePlus; HPRD; phosphoELM
S735SSPAEsSPEDSPhosphoSitePlus; HPRD; phosphoELM
S430LQHSRsMSMPVPhosphoSitePlus
S1283PGDKSsWGRTRHPRD; phosphoELM
S1103VASPTsGVKRLPhosphoSitePlus; HPRD; phosphoELM
S306RPRSKsQSSGSIKK_groupphosphoELM; RegPhos
S1162TVTPVsPSFAHPhosphoSitePlus; HPRD; phosphoELM
S388VSVAGsPLSPGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1109GVKRLsLMEQVPhosphoSitePlus; HPRD; phosphoELM
T314SGSSAtHPISVPhosphoSitePlus
Y1253QNGLNyIAIDVPhosphoSitePlus
S1164TPVSPsFAHNPPhosphoSitePlus; HPRD; phosphoELM
S334VNLPPsQTGLVPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S772LNVSPsDAVTTPhosphoSitePlus; HPRD; phosphoELM
Y184GAEDSyGLVAPHPRD; phosphoELM
Y978SPLSDyMNLDFPhosphoSitePlus; HPRD
S1153SSETFsSTTTVHPRD
Y540GGGEFyGYMTMPhosphoSitePlus
Y766LPNGDyLNVSPPhosphoSitePlus
T544FYGYMtMDRPLPhosphoSitePlus
S308RSKSQsSGSSAPhosphoSitePlus; HPRD; phosphoELM
S391AGSPLsPGPVRPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y76PRLEYyESEKKPHPhosphoSitePlus
Y814SYKAPyTCGGDPhosphoSitePlus; HPRD
Y919KSPGEyINIDFHPRD; phosphoELM
S736SPAESsPEDSGPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T1202GDEPPtSPRQLPhosphoSitePlus; HPRD; phosphoELM
S550MDRPLsHCGRSPhosphoSitePlus; HPRD; phosphoELM
S577RKRTYsLTTPAPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S731GYKASsPAESSPhosphoSitePlus; HPRD; phosphoELM
Y823GDSDQyVLMSSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S985NLDFSsPKSPKHPRD
S358AAKCSsCRVRTPhosphoSitePlus; HPRD
S384GARPVsVAGSPPhosphoSitePlus; HPRD; phosphoELM
S365RVRTAsEGDGGPhosphoSitePlus; HPRD; phosphoELM
Y540GGGEFyGYMTMINSRRegPhos
T815YKAPYtCGGDSPhosphoSitePlus
S346RSRTDsLAATPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S304EFRPRsKSQSSPhosphoSitePlus
S577RKRTYsLTTPAIKK_groupphosphoELM; RegPhos
Y653GADDGyMPMTPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S679DYMPMsPASVSPhosphoSitePlus; HPRD; phosphoELM
T579RTYSLtTPARQPhosphoSitePlus; HPRD; phosphoELM
T1157FSSTTtVTPVSPhosphoSitePlus
Y978SPLSDyMNLDFINSRRegPhos
T657GYMPMtPGAALPhosphoSitePlus
S770DYLNVsPSDAVPhosphoSitePlus; HPRD; phosphoELM
S620SCPASsPKVAYPhosphoSitePlus; HPRD; phosphoELM
T575GLRKRtYSLTTPhosphoSitePlus
Y810SLPRSyKAPYTHPRD
S1148GRRRHsSETFSPhosphoSitePlus; HPRD; phosphoELM
S400VRAPLsRSHTLPhosphoSitePlus
S820TCGGDsDQYVLPhosphoSitePlus
T713AGPAPtSAAGRPhosphoSitePlus; HPRD; phosphoELM
Y675CRSDDyMPMSPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S828YVLMSsPVGRIPhosphoSitePlus; HPRD; phosphoELM
S384GARPVsVAGSPIKK_groupphosphoELM; RegPhos
T404LSRSHtLSGGCPhosphoSitePlus
S805GCCYSsLPRSYPhosphoSitePlus
S311SQSSGsSATHPPhosphoSitePlus
S312QSSGSsATHPIPhosphoSitePlus; HPRD; phosphoELM
S915PPEPKsPGEYIPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T1151RHSSEtFSSTTPhosphoSitePlus; HPRD; phosphoELM
Y75PPRLEyYESEKPHPhosphoSitePlus
S1186SLRKSsEGGVGHPRD
Y742PEDSGyMRMWCPhosphoSitePlus; HPRD; phosphoELM
T599SLDEYtLMRATPhosphoSitePlus
Y1253QNGLNyIAIDVINSRRegPhos
S388VSVAGsPLSPGIKK_groupphosphoELM; RegPhos
Y803VPGCCySSLPRPhosphoSitePlus
S306RPRSKsQSSGSPhosphoSitePlus; HPRD; phosphoELM
T891RAVRPtRLSLEPhosphoSitePlus
Y1320PPANTyASIDFPhosphoSitePlus
S714GPAPTsAAGRTHPRD; phosphoELM
S894RPTRLsLEGLPPhosphoSitePlus; HPRD; phosphoELM
S672SGSCRsDDYMPPhosphoSitePlus; HPRD
T1159STTTVtPVSPSPhosphoSitePlus; HPRD; phosphoELM
S309SKSQSsGSSATHPRD; RegPhos
S1100AARVAsPTSGVPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y632PYPEDyGDIEIINSRHPRD; RegPhos
S591PVPQPsSASLDPhosphoSitePlus
S1185VSLRKsSEGGVHPRD; phosphoELM
S505LDEYGsSPGDLPhosphoSitePlus
S523SNTPEsIAETPPhosphoSitePlus; HPRD; phosphoELM
S606MRATFsGSAGRPhosphoSitePlus; HPRD
S619PSCPAsSPKVAHPRD
S1176RHNSAsVENVSPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T580TYSLTtPARQRPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S973DSRQRsPLSDYPhosphoSitePlus; HPRD; phosphoELM
S304EFRPRsKSQSSIKK_groupphosphoELM; RegPhos
T527ESIAEtPPARDPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y632PYPEDyGDIEIPhosphoSitePlus
T777SDAVTtGTPPDPhosphoSitePlus; HPRD; phosphoELM
S342GLVRRsRTDSLHPRD

Dephosphorylation site
IRS2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000365016A1175SCOSMICLung Cancer20668451
ENSP00000365016R1286LCOSMICOvarian Cancer20668451
ENSP00000365016A293SCOSMICLung Cancer20668451
ENSP00000365016G607DCOSMICHead and Neck Cancer
ENSP00000365016P1036dupBIOMARTColorectal Cancer21930507, 21930502
ENSP00000365016A940TCOSMICRenal Cancer

Differential expressed protein
IRS2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S1100PEAARVAsPTSGVKRovarian cancer17001009PhosphoSitePlus
S1100PEAARVAsPTSGVKRmelanoma skin cancer17001009PhosphoSitePlus
Y675GSCRSDDyMPMSPAScholangiocellular carcinoma21253578PhosphoSitePlus
Y823CGGDSDQyVLMSSPVcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
JAK1_HUMANIRS2_HUMANkinase -> substrateNetPath
ZAGL2_HUMANIRS2_HUMANkinase -> substrateRegPhos
JAK3_HUMANIRS2_HUMANkinase -> substrateNetPath
FES_HUMANIRS2_HUMANkinase -> substrateNetPath
INSR_HUMANIRS2_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04930Type II diabetes mellitus
hsa04910Insulin signaling pathway
hsa04920Adipocytokine signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005829cytosolIEAcellular_component
GO:0043548phosphatidylinositol 3-kinase bindingIEAmolecular_function
GO:0008283cell proliferationIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0033673negative regulation of kinase activityIEAbiological_process
GO:0008286insulin receptor signaling pathwayISSbiological_process
GO:0032000positive regulation of fatty acid beta-oxidationIMPbiological_process
GO:0048015phosphatidylinositol-mediated signalingTASbiological_process
GO:0019901protein kinase bindingIEAmolecular_function
GO:0030890positive regulation of B cell proliferationIEAbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0009749response to glucose stimulusIEAbiological_process
GO:0008284positive regulation of cell proliferationNASbiological_process
GO:0060397JAK-STAT cascade involved in growth hormone signalTASbiological_process
GO:0007420brain developmentIEAbiological_process
GO:0010907positive regulation of glucose metabolic processIMPbiological_process
GO:0010748negative regulation of plasma membrane long-chain IMPbiological_process
GO:0045725positive regulation of glycogen biosynthetic proceIMPbiological_process
GO:0009749response to glucose stimulusISSbiological_process
GO:0030335positive regulation of cell migrationIEAbiological_process
GO:0006006glucose metabolic processTASbiological_process
GO:0002903negative regulation of B cell apoptotic processISSbiological_process
GO:0007165signal transductionTASbiological_process
GO:0008286insulin receptor signaling pathwayIEAbiological_process
GO:0032869cellular response to insulin stimulusIEAbiological_process
GO:0005158insulin receptor bindingIEAmolecular_function
GO:0004871signal transducer activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005543phospholipid bindingIEAmolecular_function
GO:0032869cellular response to insulin stimulusIMPbiological_process
GO:0002053positive regulation of mesenchymal cell proliferatIEAbiological_process
GO:0046326positive regulation of glucose importIMPbiological_process
GO:0019216regulation of lipid metabolic processTASbiological_process
GO:0032024positive regulation of insulin secretionIEAbiological_process
GO:0002903negative regulation of B cell apoptotic processIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0055088lipid homeostasisTASbiological_process
GO:0030879mammary gland developmentIEAbiological_process
GO:0033673negative regulation of kinase activityISSbiological_process
GO:0032024positive regulation of insulin secretionISSbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0030890positive regulation of B cell proliferationISSbiological_process
GO:0005515protein bindingIEAmolecular_function