Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:INS_HUMAN
Description:insulin [Source:HGNC Symbol;Acc:6081]
Location:chr11 p15.5
Node attribute:PPI(source); ligand; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y108YQLENyCN___InsulinPhosphoSitePlus

Dephosphorylation site
INS_HUMAN do not have dephosphorylation site.

Mutation site
INS_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000370731Pancreatic CancerNormal vs. CancertissueDown0.0516215274

Hyperphosphorylation site
INS_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
INS_HUMANINSR_HUMANligand -> receptorHPMR
INS_HUMANINSR_HUMANotherKEGG
CREB1_HUMANINS_HUMANTF -> target geneTRANSFAC
PDX1_HUMANINS_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04114Oocyte meiosis
hsa04140Regulation of autophagy
hsa05215Prostate cancer
hsa04910Insulin signaling pathway
hsa04930Type II diabetes mellitus
hsa04150mTOR signaling pathway
hsa04960Aldosterone-regulated sodium reabsorption
hsa04810Regulation of actin cytoskeleton
hsa04914Progesterone-mediated oocyte maturation
hsa04950Maturity onset diabetes of the young
hsa04940Type I diabetes mellitus

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0060266negative regulation of respiratory burst involved IDAbiological_process
GO:0046628positive regulation of insulin receptor signaling IDAbiological_process
GO:0005179hormone activityNASmolecular_function
GO:0045597positive regulation of cell differentiationNASbiological_process
GO:0050709negative regulation of protein secretionIDAbiological_process
GO:0045922negative regulation of fatty acid metabolic procesIMPbiological_process
GO:0051897positive regulation of protein kinase B signaling IDAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0006355regulation of transcription, DNA-dependentNASbiological_process
GO:0051000positive regulation of nitric-oxide synthase activNASbiological_process
GO:0005576extracellular regionICcellular_component
GO:0006521regulation of cellular amino acid metabolic procesIMPbiological_process
GO:0014068positive regulation of phosphatidylinositol 3-kinaIDAbiological_process
GO:0005158insulin receptor bindingIDAmolecular_function
GO:0002674negative regulation of acute inflammatory responseIDAbiological_process
GO:0030141secretory granuleTAScellular_component
GO:0050708regulation of protein secretionIDAbiological_process
GO:0050796regulation of insulin secretionTASbiological_process
GO:0045740positive regulation of DNA replicationIDAbiological_process
GO:0033861negative regulation of NAD(P)H oxidase activityIDAbiological_process
GO:0046889positive regulation of lipid biosynthetic processNASbiological_process
GO:0005796Golgi lumenTAScellular_component
GO:0045909positive regulation of vasodilationNASbiological_process
GO:2000252negative regulation of feeding behaviorIDAbiological_process
GO:0060267positive regulation of respiratory burstIDAbiological_process
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0005159insulin-like growth factor receptor bindingIPImolecular_function
GO:0050731positive regulation of peptidyl-tyrosine phosphoryIDAbiological_process
GO:0045840positive regulation of mitosisIDAbiological_process
GO:0006953acute-phase responseIDAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0050995negative regulation of lipid catabolic processNASbiological_process
GO:0031954positive regulation of protein autophosphorylationISSbiological_process
GO:0032460negative regulation of protein oligomerizationIDAbiological_process
GO:0050715positive regulation of cytokine secretionIDAbiological_process
GO:0055089fatty acid homeostasisIMPbiological_process
GO:0042177negative regulation of protein catabolic processIDAbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIDAbiological_process
GO:0032880regulation of protein localizationIDAbiological_process
GO:0045818negative regulation of glycogen catabolic processIMPbiological_process
GO:0043410positive regulation of MAPK cascadeIDAbiological_process
GO:0031018endocrine pancreas developmentTASbiological_process
GO:0045861negative regulation of proteolysisIMPbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0007267cell-cell signalingICbiological_process
GO:0042060wound healingIDAbiological_process
GO:0030335positive regulation of cell migrationISSbiological_process
GO:0000165MAPK cascadeIDAbiological_process
GO:0032270positive regulation of cellular protein metabolic IMPbiological_process
GO:0090277positive regulation of peptide hormone secretionTASbiological_process
GO:0008284positive regulation of cell proliferationIDAbiological_process
GO:0045429positive regulation of nitric oxide biosynthetic pNASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0045725positive regulation of glycogen biosynthetic proceIDAbiological_process
GO:0046631alpha-beta T cell activationIDAbiological_process
GO:0030307positive regulation of cell growthNASbiological_process
GO:0031904endosome lumenTAScellular_component
GO:0032148activation of protein kinase B activityIDAbiological_process
GO:0045908negative regulation of vasodilationNASbiological_process
GO:0042593glucose homeostasisIMPbiological_process
GO:0090336positive regulation of brown fat cell differentiatTASbiological_process
GO:0046326positive regulation of glucose importIDAbiological_process
GO:0015758glucose transportIDAbiological_process
GO:0045721negative regulation of gluconeogenesisNASbiological_process
GO:0006006glucose metabolic processIEAbiological_process
GO:0006112energy reserve metabolic processTASbiological_process
GO:0005788endoplasmic reticulum lumenTAScellular_component
GO:0043066negative regulation of apoptotic processNASbiological_process
GO:0045821positive regulation of glycolysisIMPbiological_process
GO:0002020protease bindingIPImolecular_function
GO:0022898regulation of transmembrane transporter activityIDAbiological_process