| UniProt/SwissProt ID: | INGR1_HUMAN |
| Description: | interferon gamma receptor 1 [Source:HGNC Symbol;Acc:5439] |
| Location: | chr6 q23.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S399 | LNSYHsRNCSE | PhosphoSitePlus | |
| S302 | ETKPEsKYVSL | IFNGR1 | PhosphoSitePlus |
| S327 | CEEPLsPATVP | IFNGR1 | PhosphoSitePlus |
| S289 | PKSLIsVVRSA | IFNGR1 | PhosphoSitePlus |
| Y397 | IALNSyHSRNC | PhosphoSitePlus | |
| S396 | SIALNsYHSRN | PhosphoSitePlus | |
| T298 | SATLEtKPESK | IFNGR1 | PhosphoSitePlus |
| S383 | SSSPLsSNQSE | PhosphoSitePlus | |
| Y457 | PTSFGyDKPHV | PhosphoSitePlus; HPRD; RegPhos | |
| Y304 | KPESKyVSLIT | IFNGR1 | PhosphoSitePlus |
| Y457 | PTSFGyDKPHV | JAK1 | phosphoELM; RegPhos |
| S306 | ESKYVsLITSY | IFNGR1 | PhosphoSitePlus |
| S293 | ISVVRsATLET | IFNGR1 | PhosphoSitePlus |
| S310 | VSLITsYQPFS | IFNGR1 | PhosphoSitePlus |
| T295 | VVRSAtLETKP | IFNGR1 | PhosphoSitePlus |
| T309 | YVSLItSYQPF | IFNGR1 | PhosphoSitePlus |
| Y311 | SLITSyQPFSL | IFNGR1 | PhosphoSitePlus |
| S369 | DVVPGsHLTPI | RegPhos | |
| Dephosphorylation site |
| INGR1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000356713 | S379C | COSMIC | Head and Neck Cancer | 21798897 |
| Differential expressed protein |
| INGR1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| INGR1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| JAK1_HUMAN | INGR1_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | INGR1_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05152 | Tuberculosis |
| hsa05145 | Toxoplasmosis |
| hsa05142 | Chagas disease (American trypanosomiasis) |
| hsa04630 | Jak-STAT signaling pathway |
| hsa05162 | Measles |
| hsa05164 | Influenza A |
| hsa05140 | Leishmaniasis |
| hsa05168 | Herpes simplex infection |
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa04650 | Natural killer cell mediated cytotoxicity |
| hsa04380 | Osteoclast differentiation |
| hsa05132 | Salmonella infection |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0019955 | cytokine binding | IEA | molecular_function |
| GO:0009615 | response to virus | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0004906 | interferon-gamma receptor activity | TAS | molecular_function |
| GO:0019221 | cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0060334 | regulation of interferon-gamma-mediated signaling | TAS | biological_process |
| GO:0060333 | interferon-gamma-mediated signaling pathway | TAS | biological_process |