| UniProt/SwissProt ID: | IL4RA_HUMAN |
| Description: | interleukin 4 receptor [Source:HGNC Symbol;Acc:6015] |
| Location: | chr16 p12.1 |
| Node attribute: | substrate; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y631 | SGEEGyKPFQD | HPRD; phosphoELM | |
| Y821 | SVGPTyMRVS_ | PhosphoSitePlus | |
| T756 | RSSPPtTPLRA | PhosphoSitePlus | |
| Y575 | APTSGyQEFVH | HPRD; phosphoELM | |
| Y713 | GSGIVySALTC | PhosphoSitePlus; HPRD; phosphoELM | |
| T820 | VSVGPtYMRVS | PhosphoSitePlus | |
| Y497 | AGNPAyRSFSN | PhosphoSitePlus; HPRD; phosphoELM | |
| Y603 | PGEAGyKAFSS | HPRD; phosphoELM | |
| Dephosphorylation site |
| IL4RA_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000441667 | E577K | COSMIC | Ovarian Cancer | 21720365 | ENSP00000379111 | A761T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000441667 | Q560* | COSMIC | Skin Cancer | 21984974 | ENSP00000170630 | A761T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000170630 | E577K | COSMIC | Ovarian Cancer | 21720365 | ENSP00000379111 | E577K | COSMIC | Ovarian Cancer | 21720365 | ENSP00000170630 | Q560* | COSMIC | Skin Cancer | 21984974 | ENSP00000441667 | A761T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000379111 | S196F | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000379111 | E57K | COSMIC | Melanoma | ENSP00000170630 | S196F | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000441667 | S196F | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000441667 | E57K | COSMIC | Melanoma | ENSP00000170630 | E57K | COSMIC | Melanoma | ENSP00000379111 | Q560* | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| IL4RA_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| IL4RA_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| JAK1_HUMAN | IL4RA_HUMAN | kinase -> substrate | NetPath |
| STAT6_HUMAN | IL4RA_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04630 | Jak-STAT signaling pathway |
| hsa04640 | Hematopoietic cell lineage |
| hsa04060 | Cytokine-cytokine receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0043032 | positive regulation of macrophage activation | IEA | biological_process |
| GO:0005057 | receptor signaling protein activity | TAS | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0002532 | production of molecular mediator involved in infla | IEA | biological_process |
| GO:0045626 | negative regulation of T-helper 1 cell differentia | IEA | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0004913 | interleukin-4 receptor activity | TAS | molecular_function |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0005615 | extracellular space | IEA | cellular_component |
| GO:0042127 | regulation of cell proliferation | IEA | biological_process |
| GO:0004896 | cytokine receptor activity | IEA | molecular_function |
| GO:0035771 | interleukin-4-mediated signaling pathway | TAS | biological_process |
| GO:0006955 | immune response | TAS | biological_process |
| GO:0090197 | positive regulation of chemokine secretion | IEA | biological_process |
| GO:0043560 | insulin receptor substrate binding | RCA | molecular_function |
| GO:0043627 | response to estrogen stimulus | IEA | biological_process |
| GO:0030728 | ovulation | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0045630 | positive regulation of T-helper 2 cell differentia | IEA | biological_process |