Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IL4RA_HUMAN
Description:interleukin 4 receptor [Source:HGNC Symbol;Acc:6015]
Location:chr16 p12.1
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y631SGEEGyKPFQDHPRD; phosphoELM
Y821SVGPTyMRVS_PhosphoSitePlus
T756RSSPPtTPLRAPhosphoSitePlus
Y575APTSGyQEFVHHPRD; phosphoELM
Y713GSGIVySALTCPhosphoSitePlus; HPRD; phosphoELM
T820VSVGPtYMRVSPhosphoSitePlus
Y497AGNPAyRSFSNPhosphoSitePlus; HPRD; phosphoELM
Y603PGEAGyKAFSSHPRD; phosphoELM

Dephosphorylation site
IL4RA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000441667E577KCOSMICOvarian Cancer21720365
ENSP00000379111A761TCOSMICOvarian Cancer21720365
ENSP00000441667Q560*COSMICSkin Cancer21984974
ENSP00000170630A761TCOSMICOvarian Cancer21720365
ENSP00000170630E577KCOSMICOvarian Cancer21720365
ENSP00000379111E577KCOSMICOvarian Cancer21720365
ENSP00000170630Q560*COSMICSkin Cancer21984974
ENSP00000441667A761TCOSMICOvarian Cancer21720365
ENSP00000379111S196FCOSMICHead and Neck Cancer21984974
ENSP00000379111E57KCOSMICMelanoma
ENSP00000170630S196FCOSMICHead and Neck Cancer21984974
ENSP00000441667S196FCOSMICHead and Neck Cancer21984974
ENSP00000441667E57KCOSMICMelanoma
ENSP00000170630E57KCOSMICMelanoma
ENSP00000379111Q560*COSMICSkin Cancer21984974

Differential expressed protein
IL4RA_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IL4RA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
JAK1_HUMANIL4RA_HUMANkinase -> substrateNetPath
STAT6_HUMANIL4RA_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04630Jak-STAT signaling pathway
hsa04640Hematopoietic cell lineage
hsa04060Cytokine-cytokine receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043032positive regulation of macrophage activationIEAbiological_process
GO:0005057receptor signaling protein activityTASmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0002532production of molecular mediator involved in inflaIEAbiological_process
GO:0045626negative regulation of T-helper 1 cell differentiaIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0004913interleukin-4 receptor activityTASmolecular_function
GO:0005887integral to plasma membraneTAScellular_component
GO:0005615extracellular spaceIEAcellular_component
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0004896cytokine receptor activityIEAmolecular_function
GO:0035771interleukin-4-mediated signaling pathwayTASbiological_process
GO:0006955immune responseTASbiological_process
GO:0090197positive regulation of chemokine secretionIEAbiological_process
GO:0043560insulin receptor substrate bindingRCAmolecular_function
GO:0043627response to estrogen stimulusIEAbiological_process
GO:0030728ovulationIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0045630positive regulation of T-helper 2 cell differentiaIEAbiological_process


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