| UniProt/SwissProt ID: | IL3RB_HUMAN |
| Description: | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) [Source:HGNC Symbol;Acc:2436] |
| Location: | chr22 q12.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S601 | PPHSRsLPDIL | PKA_group | phosphoELM |
| Y766 | SGFEGyVELPP | PhosphoSitePlus; HPRD; phosphoELM | |
| Y711 | GVASGyVSSAD | PhosphoSitePlus; HPRD; phosphoELM | |
| Y822 | QQVGDyCFLPG | PhosphoSitePlus; phosphoELM | |
| Y466 | RFCGIyGYRLR | PhosphoSitePlus | |
| S585 | PEKQAsSFDFN | HPRD | |
| Y628 | PGSLEyLCLPA | PhosphoSitePlus; HPRD; phosphoELM | |
| Y593 | DFNGPyLGPPH | PhosphoSitePlus; HPRD; phosphoELM | |
| S601 | PPHSRsLPDIL | PhosphoSitePlus; phosphoELM | |
| Y882 | LKQQDyLSLPP | PhosphoSitePlus | |
| S491 | LFQNGsAELWP | PhosphoSitePlus | |
| Y468 | CGIYGyRLRRK | PhosphoSitePlus | |
| Dephosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y628 | PPPGSLEyLCLPAGG | PTPN11 | HPRD |
| Y628 | PPPGSLEyLCLPAGG | PTPN6 | HPRD |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000384053 | A394V | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
| Differential expressed protein |
| IL3RB_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| Site | Motif | Peptide | Cancer name | Pubmed | Source |
|---|---|---|---|---|---|
| S601 | LGPPHSRsLPDILGQ | acute myelogenous leukemia | 19805619 | PhosphoSitePlus | |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PTN6_HUMAN | IL3RB_HUMAN | phosphatase -> substrate | HPRD |
| PTN11_HUMAN | IL3RB_HUMAN | phosphatase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04210 | Apoptosis |
| hsa04630 | Jak-STAT signaling pathway |
| hsa04060 | Cytokine-cytokine receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0007165 | signal transduction | NAS | biological_process |
| GO:0004896 | cytokine receptor activity | IEA | molecular_function |
| GO:0007585 | respiratory gaseous exchange | TAS | biological_process |
| GO:0005887 | integral to plasma membrane | NAS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0004912 | interleukin-3 receptor activity | TAS | molecular_function |
| GO:0038043 | interleukin-5-mediated signaling pathway | TAS | biological_process |
| GO:0030526 | granulocyte macrophage colony-stimulating factor r | TAS | cellular_component |
| GO:0004872 | receptor activity | TAS | molecular_function |
| GO:0036016 | cellular response to interleukin-3 | TAS | biological_process |
| GO:0004914 | interleukin-5 receptor activity | TAS | molecular_function |
| GO:0019221 | cytokine-mediated signaling pathway | IEA | biological_process |
| GO:0038156 | interleukin-3-mediated signaling pathway | TAS | biological_process |