Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IL1A_HUMAN
Description:interleukin 1, alpha [Source:HGNC Symbol;Acc:5991]
Location:chr2 q13
Node attribute:ligand; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T189LRISKtQLYVTIL1PhosphoSitePlus
S87KKRRLsLSQSIHPRD

Dephosphorylation site
IL1A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000263339E218KBIOMARTBreast Cancer21930507, 21930502
ENSP00000263339T62SCOSMICLung Cancer20668451

Differential expressed protein
IL1A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IL1A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
IL1A_HUMANIL1R1_HUMANligand -> receptorHPMR
IL1A_HUMANIL1R2_HUMANligand -> receptorHPMR
IL1A_HUMANIL1R1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05132Salmonella infection
hsa04210Apoptosis
hsa05332Graft-versus-host disease
hsa05323Rheumatoid arthritis
hsa05164Influenza A
hsa04010MAPK signaling pathway
hsa05140Leishmaniasis
hsa05152Tuberculosis
hsa05133Pertussis
hsa04640Hematopoietic cell lineage
hsa05162Measles
hsa04060Cytokine-cytokine receptor interaction
hsa04940Type I diabetes mellitus
hsa05020Prion diseases
hsa04380Osteoclast differentiation

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045766positive regulation of angiogenesisISSbiological_process
GO:0005507copper ion bindingIDAmolecular_function
GO:0010575positive regulation vascular endothelial growth faISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0010575positive regulation vascular endothelial growth faIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0045086positive regulation of interleukin-2 biosynthetic IMPbiological_process
GO:0051781positive regulation of cell divisionIEAbiological_process
GO:0005829cytosolIDAcellular_component
GO:0045766positive regulation of angiogenesisIEAbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0008285negative regulation of cell proliferationIDAbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0008283cell proliferationTASbiological_process
GO:0006955immune responseIEAbiological_process
GO:0050715positive regulation of cytokine secretionIDAbiological_process
GO:0006954inflammatory responseTASbiological_process
GO:0019221cytokine-mediated signaling pathwayIMPbiological_process
GO:0005149interleukin-1 receptor bindingIEAmolecular_function
GO:0005125cytokine activityIMPmolecular_function
GO:0034605cellular response to heatIDAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0046688response to copper ionIDAbiological_process
GO:0045840positive regulation of mitosisIMPbiological_process
GO:0001660fever generationIEAbiological_process
GO:0043066negative regulation of apoptotic processTASbiological_process


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