Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IFIT2_HUMAN
Description:interferon-induced protein with tetratricopeptide repeats 2 [Source:HGNC Symbol;Acc:5409]
Location:chr10 q23.31
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S2____MsENNKNPhosphoSitePlus
S191DNWPPsQNAIDPhosphoSitePlus
S8ENNKNsLESSLPhosphoSitePlus
S424AKMRLsKNGADPhosphoSitePlus; HPRD
Y383GNFQLyQMKCEPhosphoSitePlus

Dephosphorylation site
IFIT2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000360891P130LCOSMICMelanoma21499247
ENSP00000360891L198VCOSMICOvarian Cancer21720365
ENSP00000360891L198VTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
IFIT2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IFIT2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
IRF1_HUMANIFIT2_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
IFIT2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005783endoplasmic reticulumIDAcellular_component
GO:0032091negative regulation of protein bindingIDAbiological_process
GO:0051607defense response to virusIEAbiological_process
GO:0060337type I interferon-mediated signaling pathwayTASbiological_process
GO:0008637apoptotic mitochondrial changesTASbiological_process
GO:0043065positive regulation of apoptotic processIDAbiological_process
GO:0009615response to virusIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0035457cellular response to interferon-alphaIEAbiological_process


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