| UniProt/SwissProt ID: | IF2B_HUMAN |
| Description: | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa [Source:HGNC Symbol;Acc:3266] |
| Location: | chr20 q11.22 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y176 | ERDYTyEELLN | PhosphoSitePlus; SysPTM | |
| S2 | ____MsGDEMI | PhosphoSitePlus; SysPTM | |
| Y298 | KDTRLyFLQCE | eIF-5_eIF-2B | PhosphoSitePlus |
| S2 | DEMI | CSNK2A1 | HPRD; SysPTM |
| T36 | TQTEEtQPSET | PhosphoSitePlus | |
| T11 | MIFDPtMSKKK | HPRD; SysPTM | |
| S67 | RKKDAsDDLDD | CSNK2A1 | HPRD; SysPTM |
| S2 | MSGDEmI | CK2a1-rs | RegPhos; SysPTM |
| S67 | RKKDAsDDLDD | CK2a1 | RegPhos; SysPTM |
| T111 | DVQEPtEPEDD | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T31 | DEEGDtQTEET | PhosphoSitePlus; HPRD | |
| S67 | RKKDAsDDLDD | CK2a1-rs | RegPhos; SysPTM |
| S13 | FDPTMsKKKKK | HPRD; RegPhos; SysPTM | |
| S67 | RKKDAsDDLDD | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S2 | MSGDEmI | CK2a1 | RegPhos; SysPTM |
| S2 | DEMI | phosphoELM; SysPTM | |
| S218 | GTKKTsFVNFT | eIF-5_eIF-2B | PhosphoSitePlus |
| S218 | GTKKTsFVNFT | HPRD; RegPhos | |
| S105 | DLKIEsDVQEP | PhosphoSitePlus; HPRD; phosphoELM | |
| S2 | MSGDEmI | RegPhos; SysPTM | |
| S158 | KDDGIsFSNQT | PhosphoSitePlus; HPRD | |
| Dephosphorylation site |
| IF2B_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000364119 | K21del | BIOMART | Colorectal Cancer | 21930507, 21930502 | ENSP00000364119 | K21- | Sjoblom2006 | Intestines Cancer | 16959974 | ENSP00000364119 | R231C | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| IF2B_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| IF2B_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | IF2B_HUMAN | kinase -> substrate | RegPhos |
| CSK21_HUMAN | IF2B_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa03013 | RNA transport |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006412 | translation | TAS | biological_process |
| GO:0003723 | RNA binding | TAS | molecular_function |
| GO:0006413 | translational initiation | TAS | biological_process |
| GO:0008135 | translation factor activity, nucleic acid binding | TAS | molecular_function |
| GO:0044267 | cellular protein metabolic process | TAS | biological_process |
| GO:0005850 | eukaryotic translation initiation factor 2 complex | TAS | cellular_component |
| GO:0003743 | translation initiation factor activity | IDA | molecular_function |