Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HS105_HUMAN
Description:heat shock 105kDa/110kDa protein 1 [Source:HGNC Symbol;Acc:16969]
Location:chr13 q12.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S509EENEMsSEADMCSNK2A2HPRD
S509EENEMsSEADMCSNK2A1HPRD
S557SQSPPsPELTSHSP70PhosphoSitePlus
T815PKLERtPNGPNPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S554QQTSQsPPSPEHPRD
S509EENEMsSEADMRegPhos
T700LMKIGtPVKVRHPRD; phosphoELM
Y677TEDWLyEEGEDHSP70PhosphoSitePlus
S132ETAENsLKKPVHSP70PhosphoSitePlus
S493GIFTIsTASMVHSP70PhosphoSitePlus
S509EENEMsSEADMCK2a2RegPhos
S509EENEMsSEADMCK2a1RegPhos
S384QCAILsPAFKVphosphoELM; RegPhos
T25AGGIEtIANEFHSP70PhosphoSitePlus
T672RLLTEtEDWLYHSP70PhosphoSitePlus
S384QCAILsPAFKVHSP70PhosphoSitePlus
T700LMKIGtPVKVRHSP70PhosphoSitePlus
S31IANEFsDRCTPRegPhos
S10GLDVGsQSCYIHSP70PhosphoSitePlus
S809KPKIEsPKLERPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y89KENLSyDLVPLHSP70PhosphoSitePlus
Y688QAKQAyVDKLEHSP70PhosphoSitePlus
Y641NAVEEyVYEFRHSP70PhosphoSitePlus
S562SPELTsEENKIHPRD
T670FLRLLtETEDWHSP70PhosphoSitePlus
Y643VEEYVyEFRDKHSP70PhosphoSitePlus
T365KDISTtLNADEHSP70PhosphoSitePlus
S429HAAPFsKVLTFHSP70PhosphoSitePlus
Y14GSQSCyIAVARHSP70PhosphoSitePlus
S852PNEKNsVNMDLPhosphoSitePlus
T486KVRVNtHGIFTHSP70PhosphoSitePlus
T494IFTIStASMVEHSP70PhosphoSitePlus
S509EENEMsSEADMCK2a1-rsRegPhos
S31IANEFsDRCTPHSP70PhosphoSitePlus
S557SQSPPsPELTSHPRD; phosphoELM; RegPhos
S12DVGSQsCYIAVHSP70PhosphoSitePlus

Dephosphorylation site
HS105_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000318687M174LCOSMICOvarian Cancer21720365
ENSP00000318687E24KCOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000318687Gastric CancerMetastasiscell lineUp1.617022644
ENSP00000318687Gastric CancerMetastasiscell lineUp1.617022644
ENSP00000318687Breast CancerNormal vs. CancertissueUp0.5220739354

Hyperphosphorylation site
HS105_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANHS105_HUMANkinase -> substrateRegPhos
CSK22_HUMANHS105_HUMANkinase -> substrateHPRD
CSK21_HUMANHS105_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04141Protein processing in endoplasmic reticulum

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0000902cell morphogenesisIEAbiological_process
GO:0006986response to unfolded proteinTASbiological_process
GO:0043014alpha-tubulin bindingIEAmolecular_function
GO:0005576extracellular regionTAScellular_component
GO:0045345positive regulation of MHC class I biosynthetic prTASbiological_process
GO:0005874microtubuleIEAcellular_component
GO:0051135positive regulation of NK T cell activationTASbiological_process
GO:0051085chaperone mediated protein folding requiring cofacIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005634nucleusIDAcellular_component


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