Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HMOX1_HUMAN
Description:heme oxygenase (decycling) 1 [Source:HGNC Symbol;Acc:5013]
Location:chr22 q12.3
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T108EVIPYtPAMQRHeme_oxygenasePhosphoSitePlus
Y286VAVGLyAM___PhosphoSitePlus
S188RSRMNsLEMTPHeme_oxygenasePhosphoSitePlus
Y55VMASLyHIYVAHeme_oxygenasePhosphoSitePlus
S231KDQSPsRAPGLPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S188RSRMNsLEMTPAKT1HPRD; RegPhos
Y137HAYTRyLGDLSHPRD
Y137HAYTRyLGDLSHeme_oxygenasePhosphoSitePlus
S53KLVMAsLYHIYHeme_oxygenasePhosphoSitePlus
T252SAPVEtPRGKPPhosphoSitePlus
T192NSLEMtPAVRQHeme_oxygenasePhosphoSitePlus
S229DTKDQsPSRAPPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y58SLYHIyVALEEHeme_oxygenasePhosphoSitePlus
Y114PAMQRyVKRLHHeme_oxygenasePhosphoSitePlus

Dephosphorylation site
HMOX1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000216117P266LCOSMICCentral Nervous System Neoplasms21817013

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000216117Hepatocellular CarcinomaMetastasiscell lineDown0.5719016532
ENSP00000216117Hepatocellular CarcinomaTreatment (none vs resveratrol-treatment)cell lineUp19996131
ENSP00000216117Testicular CancerNormal vs. Cancercell lineDown18489135

Hyperphosphorylation site
HMOX1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AKT1_HUMANHMOX1_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANHMOX1_HUMANkinase -> substrateRegPhos
PRDM2_HUMANHMOX1_HUMANTF -> target geneTRANSFAC
SP1_HUMANHMOX1_HUMANTF -> target geneTRANSFAC
SP3_HUMANHMOX1_HUMANTF -> target geneTRANSFAC
HNF4A_HUMANHMOX1_HUMANTF -> target geneTRANSFAC
USF1_HUMANHMOX1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04978Mineral absorption
hsa00860Porphyrin and chlorophyll metabolism

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0034383low-density lipoprotein particle clearanceTASbiological_process
GO:0043433negative regulation of sequence-specific DNA bindiIEAbiological_process
GO:0071276cellular response to cadmium ionIEAbiological_process
GO:0019899enzyme bindingIEAmolecular_function
GO:0055085transmembrane transportTASbiological_process
GO:0043627response to estrogen stimulusIEAbiological_process
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0006979response to oxidative stressIMPbiological_process
GO:0006778porphyrin-containing compound metabolic processTASbiological_process
GO:0043392negative regulation of DNA bindingIEAbiological_process
GO:0043305negative regulation of mast cell degranulationIEAbiological_process
GO:0055072iron ion homeostasisIDAbiological_process
GO:0032764negative regulation of mast cell cytokine productiIEAbiological_process
GO:0008219cell deathISSbiological_process
GO:0016020membraneTAScellular_component
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIMPbiological_process
GO:0043066negative regulation of apoptotic processIMPbiological_process
GO:0045909positive regulation of vasodilationICbiological_process
GO:0014806smooth muscle hyperplasiaTASbiological_process
GO:0045765regulation of angiogenesisTASbiological_process
GO:0004392heme oxygenase (decyclizing) activityIEAmolecular_function
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0051090regulation of sequence-specific DNA binding transcISSbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0045766positive regulation of angiogenesisIEAbiological_process
GO:0006979response to oxidative stressIEAbiological_process
GO:0016491oxidoreductase activityIEAmolecular_function
GO:0004630phospholipase D activityIEAmolecular_function
GO:0005615extracellular spaceTAScellular_component
GO:0051260protein homooligomerizationIDAbiological_process
GO:0001666response to hypoxiaIEAbiological_process
GO:0005901caveolaIEAcellular_component
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0051090regulation of sequence-specific DNA binding transcIEAbiological_process
GO:0004871signal transducer activityIMPmolecular_function
GO:0048661positive regulation of smooth muscle cell proliferIDAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0020037heme bindingIEAmolecular_function
GO:0071456cellular response to hypoxiaIEPbiological_process
GO:0042168heme metabolic processIEAbiological_process
GO:0005789endoplasmic reticulum membraneTAScellular_component
GO:0002686negative regulation of leukocyte migrationTASbiological_process
GO:0045080positive regulation of chemokine biosynthetic procTASbiological_process
GO:0042167heme catabolic processIEAbiological_process
GO:0034101erythrocyte homeostasisIMPbiological_process
GO:0007264small GTPase mediated signal transductionIEAbiological_process
GO:0050896response to stimulusIEAbiological_process
GO:0055114oxidation-reduction processIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0008219cell deathIEAbiological_process
GO:0007243intracellular protein kinase cascadeTASbiological_process
GO:0005634nucleusISScellular_component
GO:0048662negative regulation of smooth muscle cell proliferIEAbiological_process
GO:0005730nucleolusIEAcellular_component
GO:0007588excretionICbiological_process
GO:0005634nucleusIEAcellular_component
GO:0008217regulation of blood pressureIEAbiological_process
GO:0001935endothelial cell proliferationTASbiological_process
GO:0008630intrinsic apoptotic signaling pathway in response IEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0035094response to nicotineIDAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0043619regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0006788heme oxidationIEAbiological_process
GO:0031670cellular response to nutrientIEAbiological_process
GO:0002246wound healing involved in inflammatory responseIMPbiological_process
GO:0042542response to hydrogen peroxideIEAbiological_process
GO:0006879cellular iron ion homeostasisTASbiological_process