Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HMGB1_HUMAN
Description:high mobility group box 1 [Source:HGNC Symbol;Acc:4983]
Location:chr13 q12.3
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S39ASVNFsEFSKKDUF1898; Nop14; Nucleo_P8PhosphoSitePlus
Y155KLKEKyEKDIANop14; HMG_box; Nucleo_P8PhosphoSitePlus; SysPTM
Y109LFCSEyRPKIKNop14; HMG_box; Nucleo_P8PhosphoSitePlus
S121EHPGLsIGDVAHPRD
Y162KDIAAyRAKGKHPRD; SysPTM
S15RGKMSsYAFFVDUF1898; Nop14PhosphoSitePlus
S42NFSEFsKKCSEDUF1898; Nop14; Nucleo_P8PhosphoSitePlus
S100PKRPPsAFFLFNop14; HMG_box; Nucleo_P8PhosphoSitePlus; SysPTM
T77EREMKtYIPPKNop14; Nucleo_P87PhosphoSitePlus
Y109LFCSEyRPKIKHPRD
S53RWKTMsAKEKGDUF1898; Nop14; Nucleo_P8PhosphoSitePlus
Y16GKMSSyAFFVQDUF1898; Nop14PhosphoSitePlus
Y162KDIAAyRAKGKNop14; HMG_box; Nucleo_P8PhosphoSitePlus; SysPTM
Y71ADKARyEREMKDUF1898; Nop14; Nucleo_P8PhosphoSitePlus
Y155KLKEKyEKDIAHPRD; SysPTM
S35KHPDAsVNFSEDUF1898; Nop14; Nucleo_P8PhosphoSitePlus; SysPTM
Y78REMKTyIPPKGNop14; Nucleo_P87PhosphoSitePlus
S107FFLFCsEYRPKNop14; HMG_box; Nucleo_P8PhosphoSitePlus
Y144DDKQPyEKKAANop14; HMG_box; Nucleo_P8PhosphoSitePlus
S181VKAEKsKKKKENop14; Nucleo_P87; NucleoPhosphoSitePlus
S35KHPDAsVNFSEHPRD; phosphoELM; SysPTM
S121EHPGLsIGDVANop14; HMG_box; Nucleo_P8PhosphoSitePlus
S100PKRPPsAFFLFHPRD; SysPTM

Dephosphorylation site
HMGB1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000345347D190GHPIGastric Cancer9036861
ENSP00000382417D190GHPIGastric Cancer9036861
ENSP00000343040A149EHPIGastric Cancer9036861
ENSP00000382417A149EHPIGastric Cancer9036861
ENSP00000382417G11RHPIGastric Cancer9036861
ENSP00000343040D190GHPIGastric Cancer9036861
ENSP00000384678D190GHPIGastric Cancer9036861
ENSP00000345347A149EHPIGastric Cancer9036861
ENSP00000384678G11RHPIGastric Cancer9036861
ENSP00000343040G11RHPIGastric Cancer9036861
ENSP00000345347G11RHPIGastric Cancer9036861
ENSP00000384678A149EHPIGastric Cancer9036861

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000382417Non-small cell lung carcinomaMetastasiscell lineUp17537172
ENSP00000382417Gastric CancerMetastasiscell lineUp1.917022644
ENSP00000382417Gastric CancerMetastasiscell lineUp1.917022644
ENSP00000382417LeukemiaNormal vs. CancertissueUp15501966

Hyperphosphorylation site
HMGB1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NFIC_HUMANHMGB1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
HMGB1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045860positive regulation of protein kinase activityIEAbiological_process
GO:0006309apoptotic DNA fragmentationTASbiological_process
GO:0008134transcription factor bindingIPImolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0043388positive regulation of DNA bindingIDAbiological_process
GO:0017053transcriptional repressor complexIDAcellular_component
GO:0001654eye developmentIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0009986cell surfaceIDAcellular_component
GO:2000426negative regulation of apoptotic cell clearanceIEAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0006357regulation of transcription from RNA polymerase IIIDAbiological_process
GO:0050786RAGE receptor bindingISSmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0006310DNA recombinationISSbiological_process
GO:0000793condensed chromosomeIDAcellular_component
GO:0030324lung developmentIEAbiological_process
GO:0043280positive regulation of cysteine-type endopeptidaseIDAbiological_process
GO:0051103DNA ligation involved in DNA repairISSbiological_process
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0045087innate immune responseTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0002437inflammatory response to antigenic stimulusIEPbiological_process
GO:0043065positive regulation of apoptotic processIDAbiological_process
GO:0051384response to glucocorticoid stimulusIEAbiological_process
GO:0006288base-excision repair, DNA ligationIDAbiological_process
GO:0030295protein kinase activator activityIEAmolecular_function
GO:0006265DNA topological changeISSbiological_process
GO:0006921cellular component disassembly involved in executiTASbiological_process
GO:0042056chemoattractant activityISSmolecular_function
GO:0050918positive chemotaxisISSbiological_process
GO:0017055negative regulation of RNA polymerase II transcripIDAbiological_process
GO:0045819positive regulation of glycogen catabolic processIEAbiological_process
GO:0003684damaged DNA bindingISSmolecular_function
GO:0010858calcium-dependent protein kinase regulator activitIEAmolecular_function
GO:0008301DNA binding, bendingISSmolecular_function
GO:0005125cytokine activityIEAmolecular_function
GO:0001773myeloid dendritic cell activationISSbiological_process
GO:0000122negative regulation of transcription from RNA polyIMPbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003690double-stranded DNA bindingISSmolecular_function
GO:0005576extracellular regionTAScellular_component
GO:0045639positive regulation of myeloid cell differentiatioIEAbiological_process
GO:0002407dendritic cell chemotaxisISSbiological_process
GO:0033151V(D)J recombinationIDAbiological_process
GO:0001934positive regulation of protein phosphorylationIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0043005neuron projectionIEAcellular_component
GO:0003697single-stranded DNA bindingISSmolecular_function
GO:0070491repressing transcription factor bindingIPImolecular_function
GO:0031175neuron projection developmentISSbiological_process