| UniProt/SwissProt ID: | HHIP_HUMAN |
| Description: | hedgehog interacting protein [Source:HGNC Symbol;Acc:14866] |
| Location: | chr4 q31.21 |
| Node attribute: | receptor; PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y265 | IFKEPyLDIHK | PhosphoSitePlus | |
| S626 | GKCCCsPGWEG | PhosphoSitePlus | |
| Y616 | LCRNGyCTPTG | PhosphoSitePlus | |
| T620 | GYCTPtGKCCC | PhosphoSitePlus | |
| T618 | RNGYCtPTGKC | PhosphoSitePlus | |
| Y293 | AFHPNyKKNGK | PhosphoSitePlus | |
| Dephosphorylation site |
| HHIP_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000296575 | H214Q | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000296575 | D513N | BIOMART | chronic lymphocytic leukemia | 21930507, 21930502 | ENSP00000296575 | F180V | COSMIC | Melanoma | 21499247 | ENSP00000296575 | P409Q | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000296575 | P409Q | COSMIC | Ovarian Cancer | 21720365 | ENSP00000296575 | A601fs*4 | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000296575 | S568N | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000296575 | G577E | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| HHIP_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| HHIP_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| DHH_HUMAN | HHIP_HUMAN | ligand -> receptor | HPMR |
| IHH_HUMAN | HHIP_HUMAN | ligand -> receptor | HPMR |
| SHH_HUMAN | HHIP_HUMAN | ligand -> receptor | HPMR |
| HHIP_HUMAN | IHH_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05200 | Pathways in cancer |
| hsa04340 | Hedgehog signaling pathway |
| hsa05217 | Basal cell carcinoma |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | molecular_function |
| GO:0005887 | integral to plasma membrane | ISS | cellular_component |
| GO:0009968 | negative regulation of signal transduction | IDA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0048705 | skeletal system morphogenesis | ISS | biological_process |
| GO:0048705 | skeletal system morphogenesis | IEA | biological_process |
| GO:0005975 | carbohydrate metabolic process | IEA | biological_process |
| GO:0060441 | epithelial tube branching involved in lung morphog | IEA | biological_process |
| GO:0005576 | extracellular region | IEA | cellular_component |
| GO:0040036 | regulation of fibroblast growth factor receptor si | IEA | biological_process |
| GO:0009887 | organ morphogenesis | IEA | biological_process |
| GO:0097108 | hedgehog family protein binding | IPI | molecular_function |
| GO:0007224 | smoothened signaling pathway | IEA | biological_process |
| GO:0009986 | cell surface | IEA | cellular_component |
| GO:0045879 | negative regulation of smoothened signaling pathwa | ISS | biological_process |
| GO:0007405 | neuroblast proliferation | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0045879 | negative regulation of smoothened signaling pathwa | IEA | biological_process |
| GO:0009953 | dorsal/ventral pattern formation | IEA | biological_process |
| GO:0016901 | oxidoreductase activity, acting on the CH-OH group | IEA | molecular_function |
| GO:0048038 | quinone binding | IEA | molecular_function |
| GO:0005887 | integral to plasma membrane | IEA | cellular_component |
| GO:0008270 | zinc ion binding | IDA | molecular_function |