| UniProt/SwissProt ID: | HDAC7_HUMAN |
| Description: | histone deacetylase 7 [Source:HGNC Symbol;Acc:14067] |
| Location: | chr12 q13.11 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S507 | QARVLsSSETP | PhosphoSitePlus | |
| S155 | LRKTVsEPNLK | PhosphoSitePlus; RegPhos | |
| S181 | LLRKEsAPPSL | PKD1 | RegPhos |
| S358 | LSRTRsEPLPP | PhosphoSitePlus; phosphoELM; RegPhos | |
| S405 | LRQIPsAEDLE | PhosphoSitePlus | |
| S109 | TVHPNsPGIPY | PhosphoSitePlus; phosphoELM | |
| S508 | ARVLSsSETPA | PhosphoSitePlus | |
| S155 | LRKTVsEPNLK | MARK_group | phosphoELM |
| T255 | LLPAItLGLPA | PhosphoSitePlus | |
| T395 | WPLSRtRSEPL | HPRD | |
| S360 | LSRTRsEPLPP | HPRD | |
| S285 | GPILGsPHTPL | HPRD | |
| S488 | LSRAQsSPAAP | HPRD | |
| S283 | GPILGsPHTPL | PhosphoSitePlus; phosphoELM | |
| T104 | AALERtVHPNS | PhosphoSitePlus | |
| S907 | ASCPDsWVPRV | Arb2 | PhosphoSitePlus |
| S407 | LRQIPsAEDLE | HPRD | |
| S194 | LRKTVsEPNLK | HPRD | |
| S354 | LHWPLsRTRSE | PhosphoSitePlus | |
| Y114 | SPGIPyRTLEP | PhosphoSitePlus; phosphoELM | |
| S358 | LSRTRsEPLPP | PKD1 | RegPhos |
| T288 | LGSPHtPLFLP | HPRD | |
| S444 | LRQIPsAEDLE | HPRD | |
| T247 | PFALPtVSLLP | PhosphoSitePlus | |
| T356 | WPLSRtRSEPL | PhosphoSitePlus; phosphoELM | |
| T153 | FPLRKtVSEPN | PhosphoSitePlus | |
| S903 | MQRLAsCPDSW | Arb2 | PhosphoSitePlus |
| S397 | LSRTRsEPLPP | PRKD1 | HPRD |
| Y524 | TTGLIyDSVML | PhosphoSitePlus | |
| T511 | LSSSEtPARTL | PhosphoSitePlus | |
| S486 | LSRAQsSPAAP | PhosphoSitePlus; phosphoELM; RegPhos | |
| S526 | SRAQSsPAAPA | HPRD | |
| S525 | LSRAQsSPAAP | HPRD | |
| S489 | SRAQSsPAAPA | HPRD | |
| S220 | LLRKEsAPPSL | PRKD1 | HPRD |
| T325 | LGSPHtPLFLP | HPRD | |
| S487 | SRAQSsPAAPA | PhosphoSitePlus; phosphoELM; RegPhos | |
| T358 | WPLSRtRSEPL | HPRD | |
| S322 | GPILGsPHTPL | HPRD | |
| T286 | LGSPHtPLFLP | PhosphoSitePlus; phosphoELM | |
| T366 | LPPSAtAPPPP | PhosphoSitePlus | |
| S194 | LRKTVsEPNLK | PRKD1 | HPRD |
| S49 | EPMRLsMDTPM | PhosphoSitePlus | |
| S155 | LRKTVsEPNLK | PKD1 | phosphoELM; RegPhos |
| T301 | PEAGGtLPSRL | PhosphoSitePlus | |
| S148 | TVHPNsPGIPY | HPRD | |
| S220 | LLRKEsAPPSL | HPRD | |
| T515 | ETPARtLPFTT | PhosphoSitePlus | |
| S493 | PAAPAsLSAPE | PhosphoSitePlus | |
| S181 | LLRKEsAPPSL | PhosphoSitePlus | |
| Dephosphorylation site |
| HDAC7_HUMAN do not have dephosphorylation site. |
| Mutation site |
| HDAC7_HUMAN do not have mutation site. |
| Differential expressed protein |
| HDAC7_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| HDAC7_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | HDAC7_HUMAN | kinase -> substrate | RegPhos |
| PKD1_HUMAN | HDAC7_HUMAN | kinase -> substrate | RegPhos |
| KPCD2_HUMAN | HDAC7_HUMAN | kinase -> substrate | NetPath |
| ARAF_HUMAN | HDAC7_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | HDAC7_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05034 | Alcoholism |
| hsa05203 | Viral carcinogenesis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0090050 | positive regulation of cell migration involved in | IMP | biological_process |
| GO:0003714 | transcription corepressor activity | IEA | molecular_function |
| GO:0007219 | Notch signaling pathway | TAS | biological_process |
| GO:0046969 | NAD-dependent histone deacetylase activity (H3-K9 | IEA | molecular_function |
| GO:0004407 | histone deacetylase activity | IEA | molecular_function |
| GO:0001570 | vasculogenesis | IEA | biological_process |
| GO:0071889 | 14-3-3 protein binding | IDA | molecular_function |
| GO:0045668 | negative regulation of osteoblast differentiation | IMP | biological_process |
| GO:0016568 | chromatin modification | IEA | biological_process |
| GO:0005080 | protein kinase C binding | IPI | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0007043 | cell-cell junction assembly | IEA | biological_process |
| GO:0000118 | histone deacetylase complex | IEA | cellular_component |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0046970 | NAD-dependent histone deacetylase activity (H4-K16 | IEA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0097372 | NAD-dependent histone deacetylase activity (H3-K18 | IEA | molecular_function |
| GO:0032041 | NAD-dependent histone deacetylase activity (H3-K14 | IEA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0032703 | negative regulation of interleukin-2 production | IDA | biological_process |
| GO:0003682 | chromatin binding | IEA | molecular_function |
| GO:0033613 | activating transcription factor binding | IPI | molecular_function |
| GO:0070491 | repressing transcription factor binding | IPI | molecular_function |
| GO:0019901 | protein kinase binding | IPI | molecular_function |
| GO:0000122 | negative regulation of transcription from RNA poly | IEA | biological_process |