| UniProt/SwissProt ID: | HAP1_HUMAN |
| Description: | huntingtin-associated protein 1 [Source:HGNC Symbol;Acc:4812] |
| Location: | chrHG185_PATCH q21.2 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y440 | DLREKyMDCGG | HAP1_N | PhosphoSitePlus |
| S662 | ALPAAsRTSCR | PhosphoSitePlus | |
| Dephosphorylation site |
| HAP1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000334002 | T170S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000334002 | A522G | COSMIC | Ovarian Cancer | 21720365 | ENSP00000334002 | M400I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000334002 | *620Y | COSMIC | Intestines Cancer | 16959974 |
| Differential expressed protein |
| HAP1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| HAP1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SP1_HUMAN | HAP1_HUMAN | TF -> target gene | TRANSFAC |
| USF1_HUMAN | HAP1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| HAP1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0047496 | vesicle transport along microtubule | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005856 | cytoskeleton | TAS | cellular_component |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0008104 | protein localization | IMP | biological_process |
| GO:0015629 | actin cytoskeleton | TAS | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0016023 | cytoplasmic membrane-bounded vesicle | IEA | cellular_component |
| GO:0007420 | brain development | NAS | biological_process |