Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HAND1_HUMAN
Description:heart and neural crest derivatives expressed 1 [Source:HGNC Symbol;Acc:4807]
Location:chr5 q33.2
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S109RRRTEsINSAFPKC_groupphosphoELM; RegPhos
T107KERRRtESINSPKCaRegPhos
S98GRRKGsGPKKEPRKCAHPRD
T107KERRRtESINSPKC_groupphosphoELM; RegPhos
T107KERRRtESINSPKA_groupphosphoELM; RegPhos
T107KERRRtESINSPRKACAHPRD
T107KERRRtESINSPRKCAHPRD
S98GRRKGsGPKKEHLHPhosphoSitePlus
S109RRRTEsINSAFPRKCAHPRD
S109RRRTEsINSAFPKACaRegPhos
S98GRRKGsGPKKEPKACaRegPhos
S98GRRKGsGPKKEPKCaRegPhos
S98GRRKGsGPKKEPKC_groupphosphoELM; RegPhos
T107KERRRtESINSPKACaRegPhos
S109RRRTEsINSAFPKCaRegPhos
S98GRRKGsGPKKEPKA_groupphosphoELM; RegPhos
S109RRRTEsINSAFPKA_groupphosphoELM; RegPhos
S98GRRKGsGPKKEPRKACAHPRD
S109RRRTEsINSAFPRKACAHPRD

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S109KERRRTEsINSAFAEPPP2R5DHPRD
T107PKKERRRtESINSAFPPP2R5DHPRD

Mutation site
HAND1_HUMAN do not have mutation site.

Differential expressed protein
HAND1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
HAND1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANHAND1_HUMANkinase -> substrateHPRD
2A5D_HUMANHAND1_HUMANphosphatase -> substrateHPRD
SP4_HUMANHAND1_HUMANTF -> target geneTRANSFAC
SP1_HUMANHAND1_HUMANTF -> target geneTRANSFAC
SP3_HUMANHAND1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
HAND1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005654nucleoplasmIEAcellular_component
GO:0060485mesenchyme developmentIEAbiological_process
GO:0035050embryonic heart tube developmentISSbiological_process
GO:0005634nucleusIEAcellular_component
GO:0046983protein dimerization activityIEAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0007507heart developmentISSbiological_process
GO:0060411cardiac septum morphogenesisIMPbiological_process
GO:0003713transcription coactivator activityIDAmolecular_function
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0003219cardiac right ventricle formationIMPbiological_process
GO:0001947heart loopingISSbiological_process
GO:0003144embryonic heart tube formationIEAbiological_process
GO:0043433negative regulation of sequence-specific DNA bindiIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0008134transcription factor bindingIEAmolecular_function
GO:0043425bHLH transcription factor bindingIPImolecular_function
GO:0030154cell differentiationIEAbiological_process
GO:0055010ventricular cardiac muscle tissue morphogenesisIEAbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0001525angiogenesisISSbiological_process
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0001829trophectodermal cell differentiationIEPbiological_process
GO:0035050embryonic heart tube developmentIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0055010ventricular cardiac muscle tissue morphogenesisIMPbiological_process
GO:0006366transcription from RNA polymerase II promoterIDAbiological_process
GO:0042802identical protein bindingISSmolecular_function
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0042802identical protein bindingIEAmolecular_function
GO:0042475odontogenesis of dentin-containing toothIEAbiological_process
GO:0001947heart loopingIEAbiological_process
GO:0060536cartilage morphogenesisIEAbiological_process
GO:0060707trophoblast giant cell differentiationIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0001824blastocyst developmentIEPbiological_process
GO:0008134transcription factor bindingIPImolecular_function
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0005730nucleolusIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0061371determination of heart left/right asymmetryIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0007507heart developmentIEAbiological_process
GO:0019899enzyme bindingIEAmolecular_function
GO:0042803protein homodimerization activityNASmolecular_function
GO:0003218cardiac left ventricle formationIMPbiological_process
GO:0001707mesoderm formationIEAbiological_process