Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GRIA4_HUMAN
Description:glutamate receptor, ionotropic, AMPA 4 [Source:HGNC Symbol;Acc:4574]
Location:chr11 q22.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T850KRMKLtFSEAIPKCaRegPhos
S862NKARLsITGSVPKACaRegPhos
S862NKARLsITGSVPhosphoSitePlus
T850KRMKLtFSEAIPKC_groupphosphoELM; RegPhos
S314AETFRsLRRQKANF_receptorPhosphoSitePlus
S314AETFRsLRRQKHPRD
S862NKARLsITGSVPRKCAHPRD
S862NKARLsITGSVPKA_groupphosphoELM; RegPhos
S862NKARLsITGSVCAMK2GHPRD
S862NKARLsITGSVPKC_groupphosphoELM; RegPhos
S514EVIDFsKPFMSPhosphoSitePlus
T850KRMKLtFSEAIPRKCAHPRD
S862NKARLsITGSVPRKACAHPRD
Y838LIEFCyKSRAEPhosphoSitePlus
S862NKARLsITGSVPKCaRegPhos
S862NKARLsITGSVCaMK2gRegPhos

Dephosphorylation site
GRIA4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000282499G256ECOSMICMelanoma21499247
ENSP00000282499P61ABIOMARTBreast Cancer21930507, 21930502
ENSP00000282499P384HTCGAOvarian Cancer21720365, 18772890
ENSP00000435775I498NCOSMICHepatocellular Carcinoma21822264
ENSP00000435775A699PCOSMICOvarian Cancer21720365
ENSP00000282499G470ECOSMICMelanoma
ENSP00000282499I498NCOSMICHepatocellular Carcinoma21822264
ENSP00000282499P384HCOSMICOvarian Cancer21720365
ENSP00000435775L32PTCGAOvarian Cancer21720365, 18772890
ENSP00000415551*434YCOSMICOvarian Cancer20826764
ENSP00000376833R368CBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000435775W628*COSMICCentral Nervous System Neoplasms18772396
ENSP00000282499L32PCOSMICOvarian Cancer21720365
ENSP00000435775G470ECOSMICMelanoma
ENSP00000435775P61ABIOMARTBreast Cancer21930507, 21930502
ENSP00000435775L32PCOSMICOvarian Cancer21720365
ENSP00000435775P384HCOSMICOvarian Cancer21720365
ENSP00000435775G256ECOSMICMelanoma21499247
ENSP00000282499G126WCOSMICHead and Neck Cancer21798893
ENSP00000282499W628*COSMICCentral Nervous System Neoplasms18772396
ENSP00000282499A699PCOSMICOvarian Cancer21720365
ENSP00000282499P570SCOSMICHead and Neck Cancer21984974
ENSP00000435775G126WCOSMICHead and Neck Cancer21798893
ENSP00000376833P61ABIOMARTBreast Cancer21930507, 21930502
ENSP00000435775P570SCOSMICHead and Neck Cancer21984974
ENSP00000376833*434YCOSMICOvarian Cancer20826764
ENSP00000435775P384HTCGAOvarian Cancer21720365, 18772890
ENSP00000282499L32PTCGAOvarian Cancer21720365, 18772890
ENSP00000415551P61ABIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
GRIA4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GRIA4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANGRIA4_HUMANkinase -> substrateHPRD
KCC2G_HUMANGRIA4_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04724Glutamatergic synapse
hsa04723Retrograde endocannabinoid signaling
hsa05031Amphetamine addiction
hsa04728Dopaminergic synapse
hsa04080Neuroactive ligand-receptor interaction
hsa05033Nicotine addiction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005886plasma membraneTAScellular_component
GO:0032281alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropioniIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0004971alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionIDAmolecular_function
GO:0007268synaptic transmissionTASbiological_process
GO:0005234extracellular-glutamate-gated ion channel activityIEAmolecular_function
GO:0032983kainate selective glutamate receptor complexISScellular_component
GO:0035235ionotropic glutamate receptor signaling pathwayISSbiological_process
GO:0030288outer membrane-bounded periplasmic spaceIEAcellular_component
GO:0016020membraneIEAcellular_component
GO:0030425dendriteIEAcellular_component
GO:0006810transportTASbiological_process
GO:0045211postsynaptic membraneIEAcellular_component
GO:0030666endocytic vesicle membraneTAScellular_component
GO:0030054cell junctionIEAcellular_component
GO:0007215glutamate receptor signaling pathwayTASbiological_process
GO:0004970ionotropic glutamate receptor activityISSmolecular_function
GO:0005215transporter activityIEAmolecular_function
GO:0015277kainate selective glutamate receptor activityISSmolecular_function


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23