| UniProt/SwissProt ID: | GRIA4_HUMAN |
| Description: | glutamate receptor, ionotropic, AMPA 4 [Source:HGNC Symbol;Acc:4574] |
| Location: | chr11 q22.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T850 | KRMKLtFSEAI | PKCa | RegPhos |
| S862 | NKARLsITGSV | PKACa | RegPhos |
| S862 | NKARLsITGSV | PhosphoSitePlus | |
| T850 | KRMKLtFSEAI | PKC_group | phosphoELM; RegPhos |
| S314 | AETFRsLRRQK | ANF_receptor | PhosphoSitePlus |
| S314 | AETFRsLRRQK | HPRD | |
| S862 | NKARLsITGSV | PRKCA | HPRD |
| S862 | NKARLsITGSV | PKA_group | phosphoELM; RegPhos |
| S862 | NKARLsITGSV | CAMK2G | HPRD |
| S862 | NKARLsITGSV | PKC_group | phosphoELM; RegPhos |
| S514 | EVIDFsKPFMS | PhosphoSitePlus | |
| T850 | KRMKLtFSEAI | PRKCA | HPRD |
| S862 | NKARLsITGSV | PRKACA | HPRD |
| Y838 | LIEFCyKSRAE | PhosphoSitePlus | |
| S862 | NKARLsITGSV | PKCa | RegPhos |
| S862 | NKARLsITGSV | CaMK2g | RegPhos |
| Dephosphorylation site |
| GRIA4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000282499 | G256E | COSMIC | Melanoma | 21499247 | ENSP00000282499 | P61A | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000282499 | P384H | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000435775 | I498N | COSMIC | Hepatocellular Carcinoma | 21822264 | ENSP00000435775 | A699P | COSMIC | Ovarian Cancer | 21720365 | ENSP00000282499 | G470E | COSMIC | Melanoma | ENSP00000282499 | I498N | COSMIC | Hepatocellular Carcinoma | 21822264 | ENSP00000282499 | P384H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000435775 | L32P | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000415551 | *434Y | COSMIC | Ovarian Cancer | 20826764 | ENSP00000376833 | R368C | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000435775 | W628* | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000282499 | L32P | COSMIC | Ovarian Cancer | 21720365 | ENSP00000435775 | G470E | COSMIC | Melanoma | ENSP00000435775 | P61A | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000435775 | L32P | COSMIC | Ovarian Cancer | 21720365 | ENSP00000435775 | P384H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000435775 | G256E | COSMIC | Melanoma | 21499247 | ENSP00000282499 | G126W | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000282499 | W628* | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000282499 | A699P | COSMIC | Ovarian Cancer | 21720365 | ENSP00000282499 | P570S | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000435775 | G126W | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000376833 | P61A | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000435775 | P570S | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000376833 | *434Y | COSMIC | Ovarian Cancer | 20826764 | ENSP00000435775 | P384H | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000282499 | L32P | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000415551 | P61A | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| GRIA4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| GRIA4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | GRIA4_HUMAN | kinase -> substrate | HPRD |
| KCC2G_HUMAN | GRIA4_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04724 | Glutamatergic synapse |
| hsa04723 | Retrograde endocannabinoid signaling |
| hsa05031 | Amphetamine addiction |
| hsa04728 | Dopaminergic synapse |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa05033 | Nicotine addiction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0032281 | alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropioni | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0004971 | alpha-amino-3-hydroxy-5-methyl-4-isoxazole propion | IDA | molecular_function |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0005234 | extracellular-glutamate-gated ion channel activity | IEA | molecular_function |
| GO:0032983 | kainate selective glutamate receptor complex | ISS | cellular_component |
| GO:0035235 | ionotropic glutamate receptor signaling pathway | ISS | biological_process |
| GO:0030288 | outer membrane-bounded periplasmic space | IEA | cellular_component |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0030425 | dendrite | IEA | cellular_component |
| GO:0006810 | transport | TAS | biological_process |
| GO:0045211 | postsynaptic membrane | IEA | cellular_component |
| GO:0030666 | endocytic vesicle membrane | TAS | cellular_component |
| GO:0030054 | cell junction | IEA | cellular_component |
| GO:0007215 | glutamate receptor signaling pathway | TAS | biological_process |
| GO:0004970 | ionotropic glutamate receptor activity | ISS | molecular_function |
| GO:0005215 | transporter activity | IEA | molecular_function |
| GO:0015277 | kainate selective glutamate receptor activity | ISS | molecular_function |