| UniProt/SwissProt ID: | GRAB_HUMAN |
| Description: | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) [Source:HGNC Symbol;Acc:4709] |
| Location: | chr14 q12 |
| Node attribute: | ligand |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T150 | AGWGQtAPLGK | Trypsin | PhosphoSitePlus |
| Dephosphorylation site |
| GRAB_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000216341 | *248K | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| GRAB_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| GRAB_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GRAB_HUMAN | MPRI_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05202 | Transcriptional misregulation in cancer |
| hsa05330 | Allograft rejection |
| hsa04650 | Natural killer cell mediated cytotoxicity |
| hsa04940 | Type I diabetes mellitus |
| hsa05320 | Autoimmune thyroid disease |
| hsa05332 | Graft-versus-host disease |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0019835 | cytolysis | IEA | biological_process |
| GO:0001772 | immunological synapse | TAS | cellular_component |
| GO:0006922 | cleavage of lamin involved in execution phase of a | IDA | biological_process |
| GO:0004252 | serine-type endopeptidase activity | TAS | molecular_function |
| GO:0006915 | apoptotic process | TAS | biological_process |
| GO:0003824 | catalytic activity | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0008236 | serine-type peptidase activity | TAS | molecular_function |
| GO:0006508 | proteolysis | IEA | biological_process |
| GO:0005634 | nucleus | TAS | cellular_component |
| GO:0043231 | intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |