Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GPX1_HUMAN
Description:glutathione peroxidase 1 [Source:HGNC Symbol;Acc:4553]
Location:chr3 p21.31
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S180PLRRYsRRFQTPhosphoSitePlus
Y98LNSLKyVRPGGGSHPxPhosphoSitePlus
Y96LNSLKyVRPGGAbl2phosphoELM
Y96LNSLKyVRPGGABL2RegPhos
Y98LNSLKyVRPGGABL1HPRD
Y98LNSLKyVRPGGABL2HPRD
Y96LNSLKyVRPGGAblphosphoELM
Y96LNSLKyVRPGGABL1RegPhos

Dephosphorylation site
GPX1_HUMAN do not have dephosphorylation site.

Mutation site
GPX1_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000407375Hepatocellular CarcinomaNormal vs. CancertissueDown0.1115759316
ENSP00000407375Breast CancerMetastasistissueDown0.3418416831
ENSP00000407375chronic lymphocytic leukemiaCancer vs. Cancer (agressive)tissueUp316083281
ENSP00000407375Neoplasms by Histologic TypeCancer vs. Cancer (sporadic systemic lymphomas (SSLs) vs. primary CNS lymphomas(PCNSLs))cell lineDown18759588

Hyperphosphorylation site
GPX1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ABL1_HUMANGPX1_HUMANkinase -> substrateHPRD; RegPhos
ABL2_HUMANGPX1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa00590Arachidonic acid metabolism
hsa05016Huntington's disease
hsa00480Glutathione metabolism
hsa05014Amyotrophic lateral sclerosis (ALS)

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0009636response to toxinIEAbiological_process
GO:0008283cell proliferationIEAbiological_process
GO:0004602glutathione peroxidase activityIDAmolecular_function
GO:0001836release of cytochrome c from mitochondriaIMPbiological_process
GO:0051702interaction with symbiontIEAbiological_process
GO:0008631intrinsic apoptotic signaling pathway in response IEAbiological_process
GO:0006749glutathione metabolic processIDAbiological_process
GO:0042542response to hydrogen peroxideIMPbiological_process
GO:0045454cell redox homeostasisIDAbiological_process
GO:0006629lipid metabolic processIEAbiological_process
GO:0010269response to selenium ionIMPbiological_process
GO:0040029regulation of gene expression, epigeneticIDAbiological_process
GO:0048741skeletal muscle fiber developmentIEAbiological_process
GO:0033194response to hydroperoxideIEAbiological_process
GO:0043066negative regulation of apoptotic processIMPbiological_process
GO:0006641triglyceride metabolic processIEAbiological_process
GO:0004602glutathione peroxidase activityIEAmolecular_function
GO:0009609response to symbiotic bacteriumIEAbiological_process
GO:0014902myotube differentiationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0000302response to reactive oxygen speciesIEAbiological_process
GO:0004866endopeptidase inhibitor activityIDAmolecular_function
GO:0043523regulation of neuron apoptotic processIEAbiological_process
GO:0045444fat cell differentiationIEAbiological_process
GO:0002862negative regulation of inflammatory response to anIEAbiological_process
GO:0061136regulation of proteasomal protein catabolic procesIDAbiological_process
GO:0051450myoblast proliferationIEAbiological_process
GO:0043154negative regulation of cysteine-type endopeptidaseIMPbiological_process
GO:0060055angiogenesis involved in wound healingIEAbiological_process
GO:0055114oxidation-reduction processIEAbiological_process
GO:0009611response to woundingIEAbiological_process
GO:0018158protein oxidationIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0043403skeletal muscle tissue regenerationIEAbiological_process
GO:0006144purine nucleobase metabolic processTASbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0001659temperature homeostasisIEAbiological_process
GO:0006195purine nucleotide catabolic processTASbiological_process
GO:0006917induction of apoptosisIEAbiological_process
GO:0060047heart contractionIEAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0017124SH3 domain bindingIPImolecular_function
GO:0042311vasodilationIEAbiological_process
GO:0009410response to xenobiotic stimulusIEAbiological_process
GO:0051897positive regulation of protein kinase B signaling IEAbiological_process
GO:0055086nucleobase-containing small molecule metabolic proTASbiological_process
GO:0007605sensory perception of soundIEAbiological_process
GO:0042744hydrogen peroxide catabolic processIDAbiological_process
GO:0001885endothelial cell developmentIEAbiological_process
GO:0033599regulation of mammary gland epithelial cell prolifIMPbiological_process
GO:0043534blood vessel endothelial cell migrationIEAbiological_process
GO:0060047heart contractionIMPbiological_process
GO:0006979response to oxidative stressIEAbiological_process
GO:0042744hydrogen peroxide catabolic processIEAbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0009650UV protectionIMPbiological_process
GO:0010332response to gamma radiationIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0005739mitochondrionIDAcellular_component