Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GELS_HUMAN
Description:gelsolin [Source:HGNC Symbol;Acc:4620]
Location:chr9 q33.2
Node attribute:substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T265VSEEGtEPEAMGelsolinPhosphoSitePlus
S261ARVHVsEEGTEGelsolinPhosphoSitePlus
Y465VDPATyGQFYGSrcRegPhos
Y600GGKAAyRTSPRCSKHPRD
Y409GLGLSyLSSHIPhosphoSitePlus
Y465VDPATyGQFYGGelsolinPhosphoSitePlus
Y409GLGLSyLSSHISRCRegPhos
S473FYGGDsYIILYGelsolinPhosphoSitePlus
Y465VDPATyGQFYGSRCphosphoELM; RegPhos
Y651GGKAAyRTSPRCSKRegPhos
Y603TPSAAyLWVGTCSKRegPhos
Y552TPSAAyLWVGTCSKHPRD
Y478SYIILyNYRHGGelsolinPhosphoSitePlus
Y35VPTNLyGDFFTCSKHPRD
S51EARPNsMVVEHPhosphoSitePlus
Y651GGKAAyRTSPRSRCRegPhos
Y414VDPATyGQFYGCSKHPRD
Y86VPTNLyGDFFTSRCRegPhos
Y603TPSAAyLWVGTGelsolinPhosphoSitePlus
Y480IILYNyRHGGRGelsolinPhosphoSitePlus
T361KAALKtASDFIHPRD
Y603TPSAAyLWVGTSRCRegPhos
Y409GLGLSyLSSHICSKRegPhos
Y651GGKAAyRTSPRPhosphoSitePlus
Y465VDPATyGQFYGCSKRegPhos
S261ARVHVsEEGTEHPRD
T310KAALKtASDFIHPRD
Y86VPTNLyGDFFTCSKRegPhos
Y358GLGLSyLSSHICSKHPRD
S210ARVHVsEEGTEHPRD
Y86VPTNLyGDFFTGelsolinPhosphoSitePlus

Dephosphorylation site
GELS_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000362929S560NCOSMICBreast Cancer16959974
ENSP00000362924S611NSjoblom2006, HPI, BIOMARTBreast Cancer16959974, 21930507, 21930502
ENSP00000362924S22LSjoblom2006, HPI, BIOMARTBreast Cancer16959974, 21930507, 21930502
ENSP00000362924F756STCGAOvarian Cancer21720365, 18772890
ENSP00000362929F705SCOSMICOvarian Cancer21720365
ENSP00000362924T201ISjoblom2006, HPI, BIOMARTBreast Cancer16959974, 21930507, 21930502
ENSP00000362929T150ICOSMICBreast Cancer16959974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000362924breast ductal carcinomaNormal vs. CancertissueDown0.2114625848
ENSP00000362924Uterine CancerNormal vs. CancertissueDown17902640
ENSP00000362924Hepatocellular CarcinomaNormal vs. CancertissueUp2.317627933
ENSP00000362924pancreatic ductal adenocarcinomaNormal vs. CancertissueUp6.518366394
ENSP00000362924Oral Premalignant LesionsNormal vs. CancertissueUp119072117
ENSP00000362924Oral Premalignant LesionsNormal vs. CancertissueUp119072117
ENSP00000362924Oral Premalignant LesionsNormal vs. CancertissueDown0.9519072117
ENSP00000362924Oral Premalignant LesionsNormal vs. CancertissueUp119072117
ENSP00000362924Oral Premalignant LesionsNormal vs. CancertissueUp119072117
ENSP00000362924Oral Premalignant LesionsNormal vs. CancertissueUp1.119072117
ENSP00000362924Breast CancerNormal vs. CancertissueUp18257521
ENSP00000362924Hepatocellular CarcinomaMetastasiscell lineUp1.719016532
ENSP00000362924acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp17655343
ENSP00000362924Neoplasms by Histologic TypeCancer vs. Cancer (subtype)tissueUp6.116807943
ENSP00000362924NonmelanomaNormal vs. Cancercell lineDown0.6519243805
ENSP00000362924Pancreatic CancerNormal vs. CancertissueUp315526344
ENSP00000362924Pancreatic CancerNormal vs. CancertissueUp2.416230073

Hyperphosphorylation site
GELS_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SCYL2_HUMANGELS_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANGELS_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANGELS_HUMANkinase -> substrateRobert H Newman (2013)
CSK_HUMANGELS_HUMANkinase -> substrateRegPhos
SRC_HUMANGELS_HUMANkinase -> substrateRegPhos
FYV1_HUMANGELS_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04810Regulation of actin cytoskeleton
hsa05203Viral carcinogenesis
hsa04666Fc gamma R-mediated phagocytosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005576extracellular regionISScellular_component
GO:0014003oligodendrocyte developmentIEAbiological_process
GO:0005509calcium ion bindingTASmolecular_function
GO:0007568agingIEAbiological_process
GO:0070062extracellular vesicular exosomeIDAcellular_component
GO:0060271cilium morphogenesisIMPbiological_process
GO:0005829cytosolISScellular_component
GO:0005615extracellular spaceIEAcellular_component
GO:0015629actin cytoskeletonIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0016192vesicle-mediated transportIEAbiological_process
GO:0006921cellular component disassembly involved in executiTASbiological_process
GO:0001726ruffleIEAcellular_component
GO:0030027lamellipodiumIEAcellular_component
GO:0042246tissue regenerationIEAbiological_process
GO:0051593response to folic acidIEAbiological_process
GO:0008154actin polymerization or depolymerizationIEAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0003779actin bindingIEAmolecular_function
GO:0051014actin filament severingISSbiological_process
GO:0048015phosphatidylinositol-mediated signalingIEAbiological_process
GO:0045471response to ethanolIEAbiological_process
GO:0042060wound healingIEAbiological_process
GO:0071276cellular response to cadmium ionIEAbiological_process
GO:0030041actin filament polymerizationISSbiological_process
GO:0043234protein complexIEAcellular_component
GO:0051016barbed-end actin filament cappingTASbiological_process
GO:0030155regulation of cell adhesionIEAbiological_process
GO:0048471perinuclear region of cytoplasmIEAcellular_component


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