Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GAS6_HUMAN
Description:growth arrest-specific 6 [Source:HGNC Symbol;Acc:4168]
Location:chr13 q34
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S617ERHLRsPVLTFHPRD
S676DVPVTsAPVTALaminin_G_2PhosphoSitePlus
T680TSAPVtAFYRGLaminin_G_2PhosphoSitePlus
S633DVPVTsAPVTAHPRD
Y92YFYPRyLDCINGlaPhosphoSitePlus
T637TSAPVtAFYRGHPRD
Y87DPETDyFYPRYGlaPhosphoSitePlus
Y89ETDYFyPRYLDGlaPhosphoSitePlus
S660ERHLRsPVLTFLaminin_G_2PhosphoSitePlus

Dephosphorylation site
GAS6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000416498W253CBIOMARTBreast Cancer21930507, 21930502
ENSP00000331831W526CBIOMARTBreast Cancer21930507, 21930502
ENSP00000348003W472CBIOMARTBreast Cancer21930507, 21930502
ENSP00000331831S447NCOSMICCentral Nervous System Neoplasms18772890
ENSP00000331831A601TCOSMICCentral Nervous System Neoplasms18772396
ENSP00000331831S447NTCGANeoplasms by Histologic Type21720365, 18772890

Differential expressed protein
GAS6_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GAS6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GAS6_HUMANUFO_HUMANligand -> receptorHPMR
GAS6_HUMANMERTK_HUMANligand -> receptorHPMR
GAS6_HUMANTYRO3_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
GAS6_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030971receptor tyrosine kinase bindingIPImolecular_function
GO:2000533negative regulation of renal albumin absorptionIEAbiological_process
GO:0071363cellular response to growth factor stimulusIEAbiological_process
GO:0007050cell cycle arrestTASbiological_process
GO:0085029extracellular matrix assemblyIEAbiological_process
GO:0035457cellular response to interferon-alphaIDAbiological_process
GO:0010628positive regulation of gene expressionIDAbiological_process
GO:0006508proteolysisTASbiological_process
GO:0005796Golgi lumenTAScellular_component
GO:0046718viral entry into host cellIDAbiological_process
GO:0043277apoptotic cell clearanceIEAbiological_process
GO:2000510positive regulation of dendritic cell chemotaxisIDAbiological_process
GO:0005622intracellularIEAcellular_component
GO:2000270negative regulation of fibroblast apoptotic procesIDAbiological_process
GO:0010804negative regulation of tumor necrosis factor-mediaIDAbiological_process
GO:0019064viral entry into host cell via membrane fusion witIDAbiological_process
GO:0001786phosphatidylserine bindingIDAmolecular_function
GO:0072661protein targeting to plasma membraneIDAbiological_process
GO:0043687post-translational protein modificationTASbiological_process
GO:0050900leukocyte migrationTASbiological_process
GO:0048146positive regulation of fibroblast proliferationIDAbiological_process
GO:0043491protein kinase B signaling cascadeIEAbiological_process
GO:0009267cellular response to starvationIEAbiological_process
GO:0097028dendritic cell differentiationIEPbiological_process
GO:0043027cysteine-type endopeptidase inhibitor activity invIDAmolecular_function
GO:0001961positive regulation of cytokine-mediated signalingIMPbiological_process
GO:0001764neuron migrationIEAbiological_process
GO:0030168platelet activationTASbiological_process
GO:0031589cell-substrate adhesionIEAbiological_process
GO:0046813virion attachment, binding of host cell surface reIDAbiological_process
GO:0035690cellular response to drugIEAbiological_process
GO:0051897positive regulation of protein kinase B signaling IEAbiological_process
GO:0001934positive regulation of protein phosphorylationIEAbiological_process
GO:0033159negative regulation of protein import into nucleusIDAbiological_process
GO:0030296protein tyrosine kinase activator activityIDAmolecular_function
GO:0071333cellular response to glucose stimulusIEAbiological_process
GO:0044267cellular protein metabolic processTASbiological_process
GO:0031100organ regenerationIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0035754B cell chemotaxisIDAbiological_process
GO:0010934macrophage cytokine productionIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0019079viral genome replicationIDAbiological_process
GO:0007167enzyme linked receptor protein signaling pathwayIEAbiological_process
GO:0032689negative regulation of interferon-gamma productionIDAbiological_process
GO:0046827positive regulation of protein export from nucleusIDAbiological_process
GO:0006909phagocytosisIDAbiological_process
GO:0032825positive regulation of natural killer cell differeIDAbiological_process
GO:0001934positive regulation of protein phosphorylationISSbiological_process
GO:0070374positive regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0043433negative regulation of sequence-specific DNA bindiIDAbiological_process
GO:0050711negative regulation of interleukin-1 secretionIDAbiological_process
GO:0070527platelet aggregationTASbiological_process
GO:0097241hematopoietic stem cell migration to bone marrowIDAbiological_process
GO:0032008positive regulation of TOR signaling cascadeIEAbiological_process
GO:0008283cell proliferationTASbiological_process
GO:0032148activation of protein kinase B activityIEAbiological_process
GO:0003104positive regulation of glomerular filtrationIEAbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0048018receptor agonist activityIEAmolecular_function
GO:0007596blood coagulationIEAbiological_process
GO:0018105peptidyl-serine phosphorylationIDAbiological_process
GO:0050766positive regulation of phagocytosisIDAbiological_process
GO:0017187peptidyl-glutamic acid carboxylationTASbiological_process
GO:0032715negative regulation of interleukin-6 productionIDAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0005788endoplasmic reticulum lumenTAScellular_component
GO:0040008regulation of growthIEAbiological_process
GO:0016477cell migrationTASbiological_process
GO:0060090binding, bridgingIDAmolecular_function
GO:0033138positive regulation of peptidyl-serine phosphorylaIDAbiological_process
GO:0005245voltage-gated calcium channel activityIDAmolecular_function
GO:0071307cellular response to vitamin KIDAbiological_process
GO:0032720negative regulation of tumor necrosis factor produIDAbiological_process
GO:1900165negative regulation of interleukin-6 secretionIDAbiological_process
GO:0007155cell adhesionTASbiological_process
GO:0070168negative regulation of biomineral tissue developmeIDAbiological_process
GO:0005102receptor bindingIDAmolecular_function
GO:0070588calcium ion transmembrane transportIDAbiological_process
GO:0031093platelet alpha granule lumenTAScellular_component
GO:0045860positive regulation of protein kinase activityIDAbiological_process
GO:1900142negative regulation of oligodendrocyte apoptotic pIDAbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0061098positive regulation of protein tyrosine kinase actIDAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0043154negative regulation of cysteine-type endopeptidaseIDAbiological_process
GO:2000352negative regulation of endothelial cell apoptotic IDAbiological_process
GO:2000669negative regulation of dendritic cell apoptotic prIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0002576platelet degranulationTASbiological_process