Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:G6PI_HUMAN
Description:glucose-6-phosphate isomerase [Source:HGNC Symbol;Acc:4458]
Location:chr19 q13.11
Node attribute:ligand; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S185RVWYVsNIDGTCK2a1-rsRegPhos
T251LSTNTtKVKEFPGIPhosphoSitePlus
S185RVWYVsNIDGTCK2a1RegPhos
S247HFVALsTNTTKPGIPhosphoSitePlus
Y174EALKPySSGGPPGIPhosphoSitePlus
S185RVWYVsNIDGTCSNK2A1HPRD
T250ALSTNtTKVKEPGIPhosphoSitePlus
T61SKNLVtEDVMRPGIPhosphoSitePlus
S185RVWYVsNIDGTCK2_groupphosphoELM; RegPhos
S441LMRGKsTEEARPGIPhosphoSitePlus
Y92GEKINyTEGRAPGIPhosphoSitePlus
T109RNRSNtPILVDPGIPhosphoSitePlus; SysPTM
T248FVALStNTTKVPGIPhosphoSitePlus
Y183GPRVWyVSNIDPGIPhosphoSitePlus
S107ALRNRsNTPILPGIPhosphoSitePlus
S185RVWYVsNIDGTPGIPhosphoSitePlus
Y17KLQQWyREHRSPhosphoSitePlus
T93EKINYtEGRAVPGIPhosphoSitePlus
T412LIPVQtQHPIRPGIPhosphoSitePlus
T215SKTFTtQETITPGIPhosphoSitePlus
T109RNRSNtPILVDHPRD; SysPTM
T214ASKTFtTQETIPGIPhosphoSitePlus

Dephosphorylation site
G6PI_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000348877S367CCOSMICOvarian Cancer21720365
ENSP00000348877S367CTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000348877hepatitis C virusNormal vs. CancertissueDown0.318715028
ENSP00000348877Prostate CancerMetastasiscell lineDown0.3415102926
ENSP00000348877Breast CancerTreatment (none vs. 17b-Estradiol treatment)cell lineUp218491314
ENSP00000348877Lung CancerTreatment(none vs 20 mg/mL GTE treatment)cell lineUp8.719137550
ENSP00000348877Lung CancerTreatment(none vs 40 mg/mL GTE treatment)cell lineUp4.219137550
ENSP00000348877Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineDown0.120804217
ENSP00000348877Breast CancerNormal vs. Cancercell lineUp5.820198662
ENSP00000348877Gastric CancerTreatment (none vs. drug-resistant)cell lineDown0.6120625496

Hyperphosphorylation site
G6PI_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
G6PI_HUMANAMFR_HUMANligand -> receptorHPMR
CSK21_HUMANG6PI_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa00520Amino sugar and nucleotide sugar metabolism
hsa00010Glycolysis / Gluconeogenesis
hsa00500Starch and sucrose metabolism
hsa01100Metabolic pathways
hsa00030Pentose phosphate pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008083growth factor activityIEAmolecular_function
GO:0005975carbohydrate metabolic processIEAbiological_process
GO:0016866intramolecular transferase activityIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0005829cytosolIEAcellular_component
GO:0006094gluconeogenesisIEAbiological_process
GO:0048029monosaccharide bindingIEAmolecular_function
GO:0005125cytokine activityIEAmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0007611learning or memoryIEAbiological_process
GO:0019242methylglyoxal biosynthetic processIEAbiological_process
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0007599hemostasisTASbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0006959humoral immune responseTASbiological_process
GO:0051156glucose 6-phosphate metabolic processIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0005829cytosolTAScellular_component
GO:0006096glycolysisIEAbiological_process
GO:0004347glucose-6-phosphate isomerase activityIEAmolecular_function
GO:0046185aldehyde catabolic processIEAbiological_process
GO:0006006glucose metabolic processTASbiological_process
GO:0043005neuron projectionIEAcellular_component
GO:0005975carbohydrate metabolic processTASbiological_process
GO:0043154negative regulation of cysteine-type endopeptidaseIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0001525angiogenesisIEAbiological_process


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