Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:G3BP1_HUMAN
Description:GTPase activating protein (SH3 domain) binding protein 1 [Source:HGNC Symbol;Acc:30292]
Location:chr5 q33.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S250DLRTFsWASVTPhosphoSitePlus
S230EDAQKsSSPAPPhosphoSitePlus; HPRD; phosphoELM
S373ELRINsGGKLPHPRD; phosphoELM
S232AQKSSsPAPADPhosphoSitePlus; HPRD; phosphoELM
S7VMEKPsPLLVGPhosphoSitePlus
Y363DFFQSyGNVVERRM_1PhosphoSitePlus
Y56PADAVyGQKEIHPRD
Y133NDIFRyQDEVFNTF2PhosphoSitePlus
Y125VANKFyVHNDINTF2PhosphoSitePlus
T143FGGFVtEPQEEPhosphoSitePlus; HPRD; phosphoELM
Y56PADAVyGQKEINTF2PhosphoSitePlus
T241ADIAQtVQEDLPhosphoSitePlus; HPRD
T222PVLEEtAPEDAPhosphoSitePlus
S388VVFDDsEPVQKRRM_1PhosphoSitePlus
S231DAQKSsSPAPAPhosphoSitePlus; HPRD; phosphoELM
S373ELRINsGGKLPRRM_1PhosphoSitePlus
S253TFSWAsVTSKNPhosphoSitePlus
Y174DSGTFyDQAVVHPRD
S47HGGLDsNGKPANTF2PhosphoSitePlus
Y133NDIFRyQDEVFHPRD
S149EPQEEsEEEVEPhosphoSitePlus; HPRD; phosphoELM
T162EERQQtPEVVPPhosphoSitePlus; HPRD

Dephosphorylation site
G3BP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000377681P316RCOSMICOvarian Cancer21720365
ENSP00000377681P316RTCGAOvarian Cancer21720365, 18772890
ENSP00000348578P316RTCGAOvarian Cancer21720365, 18772890
ENSP00000377681P224SCOSMICMelanoma21499247
ENSP00000377681R423*COSMICMelanoma21499247

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000348578Lung CancerTreatment (none vs. FK228 treatment)cell lineDown18549279
ENSP00000348578Breast CancerTreatment (none vs. 17b-Estradiol treatment)cell lineUp2.918491314
ENSP00000348578Breast CancerNormal vs. Cancercell lineUp1.520543960
ENSP00000348578Breast CancerNormal vs. Cancercell lineUp1.420543960
ENSP00000348578acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.1217655343
ENSP00000348578acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.1517655343
ENSP00000348578acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.0717655343
ENSP00000348578acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.2317655343
ENSP00000348578Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
G3BP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
YES_HUMANG3BP1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
G3BP1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004519endonuclease activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0005829cytosolIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0010494cytoplasmic stress granuleIEAcellular_component
GO:0007265Ras protein signal transductionTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0004003ATP-dependent DNA helicase activityTASmolecular_function
GO:0000166nucleotide bindingIEAmolecular_function
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0005622intracellularIEAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0090090negative regulation of canonical Wnt receptor signIEAbiological_process
GO:0006810transportIEAbiological_process
GO:0004004ATP-dependent RNA helicase activityTASmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0003729mRNA bindingIEAmolecular_function


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